{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:11:45Z","timestamp":1788304305274,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased intestinal permeability may be associated with certain disorders, such as obesity and small intestine bacterial overgrowth (SIBO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate intestinal permeability and SIBO in excess weight adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 67 adolescents with excess weight and 66 normal weight adolescents. Excess weight was defined as a body mass index for age (BMI\/age)\u2009&gt;\u2009+1 SD, which includes having excess body weight and obesity. SIBO was diagnosed by a breath test after the ingestion of lactulose according to the production of hydrogen and methane. Zonulin (haptoglobin) was considered an indicator of intestinal permeability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adolescents with excess weight had a higher height\/age <jats:italic>Z<\/jats:italic>\u2010score (median [25th; 75th percentile]: +0.6 [\u22120.4; +1.0]) than those in the normal weight group (\u22120.1 [\u22120.6; +0.7]; <jats:italic>P<\/jats:italic> = .014). Zonulin (mg\/mL) in the excess weight (2.3 [1.5; 3.8]) adolescents was higher than that in the normal weight (1.6 [1.0; 2.2]) adolescents (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). SIBO was diagnosed in 23.3% (31\/133) of the adolescents. The adolescents with SIBO had a lower (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) BMI\/age (+0.6 [\u22120.6; +1.9]) and height\/age (\u22120.3 [\u22120.7; +0.3]) than the adolescents without SIBO (+1.3 [+0.1; +2.6] and\u2009+0.2 [\u22120.5; +1.0], respectively). No association was found between zonulin and SIBO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Excess weight is associated with increased intestinal permeability. No relationship was found between SIBO and intestinal permeability; however, SIBO was related to lower BMI and height for age <jats:italic>Z<\/jats:italic>\u2010scores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12741","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:30:08Z","timestamp":1603326608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intestinal permeability and small intestine bacterial overgrowth in excess weight adolescents"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6574-6506","authenticated-orcid":false,"given":"Ana Paula Bidutte","family":"Cortez","sequence":"first","affiliation":[{"name":"Post\u2010Graduate Program in Nutrition Federal University of S\u00e3o Paulo (Universidade Federal de S\u00e3o Paulo \u2013 UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Fisberg","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Federal University of S\u00e3o Paulo (Universidade Federal de S\u00e3o Paulo \u2013 UNIFESP)  S\u00e3o Paulo Brazil"},{"name":"Nutrition and Feeding Difficulties Center\u2010Pensi Institute\u2010Sabar\u00e1 Children's Hospital (Hospital Infantil Sabar\u00e1)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Batista","family":"de Morais","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Federal University of S\u00e3o Paulo (Universidade Federal de S\u00e3o Paulo \u2013 UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017-00253"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/674106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.3682"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.03.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.485325"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906773106"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1593"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20510.1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.08.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2016.1251384"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302009000200004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1086020"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13199"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-007-9398-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1239-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.46"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i24.2978"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.055"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i41.5932"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-1012-0"},{"issue":"1","key":"e_1_2_8_22_1","first-page":"22","article-title":"Intestinal methane production in obese individuals is associated with a higher body mass index","volume":"8","author":"Basseri RJ","year":"2012","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"e_1_2_8_23_1","unstructured":"ABEP.Associa\u00e7\u00e3o Brasileira de Empresas de Pesquisa. 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