{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T13:24:20Z","timestamp":1767965060924,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007582","name":"Alberta Health Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007582","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cardiovascular disease (CVD) originates in childhood and risk is exacerbated in obesity. Mechanisms of the etiologic link between early adiposity and CVD\u2010risk remain unclear. Postprandial or non\u2010fasting dyslipidemia is characterized by elevated plasma triglycerides (TG) and intestinal\u2010apolipoprotein(apo)B48\u2010remnants following a high\u2010fat meal and is a known CVD\u2010risk factor in adults. The aim of this study was to determine (a) whether the <jats:italic>fasting<\/jats:italic> concentration of apoB48\u2010remnants can predict impaired <jats:italic>non\u2010fasting<\/jats:italic> apoB48\u2010lipoprotein metabolism (fat intolerance) and (b) the relationship of these biomarkers with cardiometabolic risk factors in youth with or without obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed fasting and non\u2010fasting lipids in youth without obesity (<jats:italic>n<\/jats:italic> = 22, 10 males, 12 females) and youth with obesity (<jats:italic>n<\/jats:italic> = 13, 5 males, 8 females) with a mean BMI <jats:italic>Z<\/jats:italic>\u2010score of 0.19\u2009\u00b1\u20090.70 and 2.25\u2009\u00b1\u20090.31 (<jats:italic>P<\/jats:italic> = .04), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fasting and non\u2010fasting apoB48\u2010remnants were elevated in youth with obesity compared to youth without obesity (apoB48: 18.04\u2009\u00b1\u20091.96 vs 8.09\u2009\u00b1\u20090.59, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001, and apoB48<jats:sub>AUC<\/jats:sub>: 173.0\u2009\u00b1\u200920.86 vs 61.99\u2009\u00b1\u20093.44, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Furthermore, fasting plasma apoB48\u2010remnants were positively correlated with the non\u2010fasting response in apoB48<jats:sub>AUC<\/jats:sub> (<jats:italic>r<\/jats:italic> = 0.84, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) as well as other cardiometabolic risk factors including HOMA\u2010IR (<jats:italic>r<\/jats:italic> = 0.61, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and leptin (<jats:italic>r<\/jats:italic> = 0.56, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fasting apoB48\u2010remnants are elevated in youth with obesity and predict apoB48 postprandial dyslipidemia. ApoB48\u2010remnants are associated with the extent of fat intolerance and appear to be potential biomarker of CVD\u2010risk in youth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12745","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T01:14:00Z","timestamp":1604538840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>ApoB\u2010lipoprotein<\/scp> remnant dyslipidemia and <scp>high\u2010fat<\/scp> meal intolerance is associated with markers of cardiometabolic risk in youth with obesity"],"prefix":"10.1111","volume":"16","author":[{"given":"Jacqueline A.","family":"Krysa","sequence":"first","affiliation":[{"name":"Division of Nutrition, Metabolic and Cardiovascular Diseases Laboratory University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-3120","authenticated-orcid":false,"given":"Geoff D. 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