{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:11:25Z","timestamp":1765807885552,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["Pathways Award #1\u201015\u2010ACE\u201026"],"award-info":[{"award-number":["Pathways Award #1\u201015\u2010ACE\u201026"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["#MOP\u2010115071","#PJT\u2010152989","Team Grant #144626"],"award-info":[{"award-number":["#MOP\u2010115071","#PJT\u2010152989","Team Grant #144626"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["#20697"],"award-info":[{"award-number":["#20697"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Exposure to maternal hyperglycaemia in pregnancy has been associated with childhood obesity. Leptin regulation might be involved in this \u2018adiposity programming\u2019 and may depend on timing of exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate associations of maternal glycaemia at different periods in pregnancy with childhood adiposity and leptin levels at 5\u2009years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective pre\u2010birth cohort, we measured maternal glucose levels after a 50\u2009g oral glucose challenge test at first trimester (9.8\u00a0\u00b1\u20092.3\u2009weeks) and during a 75\u2009g oral glucose tolerance test at second trimester (26.5\u00a0\u00b1\u20090.9\u2009weeks). We followed up children at 5\u2009years; we measured anthropometry and body composition using dual\u2010energy X\u2010ray absorptiometry (DXA). We measured fasting leptin levels using immunoassays (Luminex) in 328 children. We conducted linear regression analyses, adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal glycaemia at first trimester was associated with childhood leptin levels at 5\u2009years, independently of maternal pre\u2010pregnancy BMI and other confounders (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u2009.09\u2009\u00b1\u2009.04; <jats:italic>P<\/jats:italic>\u00a0=\u2009.03). Higher post\u2010load glucose levels at second trimester were associated with greater total body fat percentage measured by DXA (1\u00a0hour\u2010glucose: <jats:italic>\u03b2<\/jats:italic>\u00a0=\u2009.010\u2009\u00b1\u2009.004; <jats:italic>P<\/jats:italic>\u00a0=\u2009.03 and 2\u00a0hours\u2010glucose: <jats:italic>\u03b2<\/jats:italic>\u00a0=\u2009.016\u2009\u00b1\u2009.005; <jats:italic>P<\/jats:italic>\u00a0=\u2009.002), but not with leptin levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that programming of leptin regulation may be sensitive to maternal hyperglycaemia specifically in early pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12788","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T06:53:51Z","timestamp":1615964031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Maternal glucose in pregnancy is associated with child's adiposity and leptin at 5\u2009years of age"],"prefix":"10.1111","volume":"16","author":[{"given":"Kasandra","family":"Blais","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Medicine Universit\u00e9 de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lina","family":"Arguin","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Allard","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Doyon","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernon W.","family":"Dolinsky","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Children's Hospital Research Institute of Manitoba University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"},{"name":"Faculty of Medicine and Health Sciences, Department of Biochemistry and Functional Genomics Universit\u00e9 de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"},{"name":"Department of Medical Biology CIUSSS of Saguenay\u2010Lac\u2010Saint\u2010Jean  Saguenay Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-2585","authenticated-orcid":false,"given":"Marie\u2010France","family":"Hivert","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Medicine Universit\u00e9 de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"},{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"},{"name":"Department of Population Medicine, Harvard Pilgrim Health Care Institute Harvard Medical School  Boston Massachusetts USA"},{"name":"Diabetes Unit Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Perron","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Department of Medicine Universit\u00e9 de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"},{"name":"Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke  Sherbrooke Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1267-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113342"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1279"},{"key":"e_1_2_11_5_1","first-page":"255","article-title":"Role of leptin in the regulation of lipid and carbohydrate metabolism","volume":"65","author":"Gogga P","year":"2011","journal-title":"Postep Hig Med Dosw Online"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-000738"},{"issue":"2","key":"e_1_2_11_7_1","first-page":"140","article-title":"Intrauterine exposure to maternal diabetes is associated with adiposity in children at 6\u2009years of age in China","volume":"28","author":"Chang 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