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Individuals born small\u2010for\u2010gestational\u2010age (SGA) with excessive postnatal catch\u2010up in weight are at risk for obesity and type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess serum concentrations of DBI (0\u20102\u2009years) in appropriate\u2010for\u2010gestational\u2010age (AGA,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200970) vs SGA infants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200933) with spontaneous catch\u2010up and their relationship with endocrine\u2010metabolic and adiposity markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Longitudinal assessments included auxology, fasting glucose, insulin, insulin\u2010like growth factor, high\u2010molecular\u2010weight adiponectin, DBI and body composition (absorptiometry). DBI was measured cross\u2010sectionally in pregnant and non\u2010pregnant women and in 2\u2010day\u2010old newborns. DBI mRNA expression levels were assessed in adult and neonatal tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cord blood DBI concentrations were similar in AGA and SGA newborns and about fivefold higher than those in women. Serum DBI levels decreased by age 2\u2009days, were higher in SGA vs AGA infants at age 2\u2009years and associated negatively with markers of adiposity and insulin resistance and positively with high\u2010molecular\u2010weight adiponectin. DBI mRNA expression was lower in placenta than in other tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The increased DBI concentrations at birth are unrelated to prenatal growth. The higher DBI levels in SGA subjects at age 2\u2009years may be related to catch\u2010up growth or represent an adaptive mechanism to promote lipogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.12802","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T06:59:11Z","timestamp":1621493951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Circulating diazepam\u2010binding inhibitor in infancy: Relation to markers of adiposity and metabolic health"],"prefix":"10.1111","volume":"16","author":[{"given":"Marta","family":"D\u00edaz","sequence":"first","affiliation":[{"name":"Endocrinology Department Pediatric Research Institute Hospital Sant Joan de D\u00e9u, University of Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), ISCIII  Madrid 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