{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:23:08Z","timestamp":1791922988001,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000544","name":"British Association for Psychopharmacology","doi-asserted-by":"publisher","award":["47\/2020\u201005"],"award-info":[{"award-number":["47\/2020\u201005"]}],"id":[{"id":"10.13039\/501100000544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) has become the most common liver disease in children and adolescents. The optimal dietary strategy to improve hepatic stetatosis and reduce oxidative stress and inflammation in adolescents is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was conducted to evaluate the effect of Mediterranean diet (MD) versus low\u2010fat diet (LFD) on hepatic steatosis, inflammation, and oxidative stress in adolescents with obesity and NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adolescents diagnosed with NAFLD between the ages of 11\u201318\u2009years were randomized to either a MD or conventional LFD (control diet) for 12\u2009weeks. Dietary status, anthropometry, body composition, and biochemical parameters were evaluated. Hepatic steatosis was determined by ultrasonography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 44 participants completed the study. At the end of the study, severity of hepatic steatosis, serum transaminase levels, and insulin resistance decreased significantly in both groups with no significant differences between groups except for aspartate aminotransferase (AST). The amount of decrease in AST levels in the MD group was greater than the LFD group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In the MD group, serum total antioxidant capacity, paraoxanase\u20101, and glutathione peroxidase levels increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); it did not change in the LFD group compared to baseline (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). C\u2010Reactive Protein (CRP) levels decreased only in the MD group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008), interleukine\u20106 decreased only in the LFD group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Consumption of MD and LFD for 12\u2009weeks in adolescents with obesity and NAFLD reduced BMI, fat mass, hepatic steatosis, and insulin resistance, improved high transaminase levels, and had positive effects on inflammation and oxidative stress.<\/jats:p><jats:p>Registered under <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> Identifier no. NCT04845373.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12872","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T06:13:13Z","timestamp":1639030393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["The effects of Mediterranean diet on hepatic steatosis, oxidative stress, and inflammation in adolescents with <scp>non\u2010alcoholic<\/scp> fatty liver disease: A randomized controlled trial"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5410-7231","authenticated-orcid":false,"given":"Gamze","family":"Yurtda\u015f","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Department of Nutrition and Dietetics Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Akbulut","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Nutrition and Dietetics Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u015fallah","family":"Baran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Gastroenterology Hepatology and Nutrition Izmir Katip Celebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biochemistry Gazi University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001482"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1595589"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.048"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.5370"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12630"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001823"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31803815d9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101052"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30076"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.02.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2017.02.008"},{"key":"e_1_2_8_13_1","unstructured":"PekcanEG \u015eanl\u0131erN Ba\u015fM Ba\u015fo\u011fluS AcarTek N.T\u00fcrkiye Beslenme Rehberi 2015 (T\u00dcBER). 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