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A candidate for such a role seems to be microRNAs, which in vivo serve as the suppressing factors in gene expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed at reviewing recent discoveries in this field and concluding directions of research or application of studied molecules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Repeated browsing of databases and screening of results, led to final approval of 16 articles. Filtered studies examined differences in microRNA expression between subjects with obesity and children suffering from its comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Studies concerning endothelial dysfunction identified molecules miR\u2010320a and miR\u2010630 as a possible diagnosis and treatment option. Search for the alternative markers in diagnosis of non\u2010alcoholic fatty liver disease suggested value of molecules: miR\u2010199a\u20105p and miR\u2010122. miR\u2010486, miR\u2010146b, and miR\u201015b may serve in grading the development of type 2 diabetes in children, although further research raised doubts. Panel of molecules was indicated as useful in early detection of metabolic syndrome and insulin resistance associated alterations. No valid link between studied microRNAs and atherosclerosis was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MicroRNAs seem to be promising prognostic markers for diagnosis of endothelial dysfunction, non\u2010alcoholic fatty liver disease, type 2 diabetes, metabolic syndrome and insulin resistance in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12880","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T06:04:20Z","timestamp":1639721060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["<scp>MicroRNAs<\/scp> as the promising markers of comorbidities in childhood obesity\u2014A systematic review"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-7542","authenticated-orcid":false,"given":"Micha\u0142","family":"Hutny","sequence":"first","affiliation":[{"name":"Scientific Society of Medical 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