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Polygenic scores were calculated as the sum of the number of risk alleles of BMI\u2010related SNPs which were weighted by effect size. A race\/ethnicity\u2010stratified mixed\u2010effects linear regression model was used to test for differential association between BMI polygenic score and BMI by the presence of ACEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We did not find any evidence of significant interaction between ACEs and polygenic score in relation to BMI among EA (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.289), AA (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.618) or HA (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.870). In main effects models, polygenic score was positively associated with BMI in all race\/ethnic groups, yet the presence of ACEs was associated with increased BMI only among EA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We did not find any evidence that ACEs exacerbate genetic predisposition to increased BMI in early adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12885","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T06:12:46Z","timestamp":1642486366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Do adverse childhood experiences and genetic obesity risk interact in relation to body mass index in young adulthood? Findings from the National Longitudinal Study of Adolescent to Adult Health"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7690-3447","authenticated-orcid":false,"given":"Yosuke","family":"Inoue","sequence":"first","affiliation":[{"name":"Carolina Population Center, The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Epidemiology and Prevention National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-1735","authenticated-orcid":false,"given":"Mariaelisa","family":"Graff","sequence":"additional","affiliation":[{"name":"Carolina Population Center, The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Epidemiology Gillings School of Global Public Health, The University of North Carolina at Chapel Hill  Chapel Hill North Carolina 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