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At the baseline and follow\u2010up visits (1.6\u20133.5\u2009years apart), anthropometry was collected to identify associations between baseline metabolite clusters and change in BC (\u2206) using seemingly unrelated and linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between visits, MM increased in boys and adiposity increased in girls. Sex differences were observed between metabolite clusters and changes in BC. In boys, aromatic amino acids (AAA), branched chain amino acids (BCAA) and fatty acid oxidation metabolites were associated with increases in \u2206BMI, and \u2206BF%. Phospholipids were associated with decreases in \u2206TS and \u2206MM. Negative associations were observed for \u2206MM in boys with a cluster including AAA and BCAA, whereas positive associations were found for a cluster containing tryptophan metabolites. Few associations were observed between metabolites and BC change in girls, with one cluster comprising methionine, proline and lipids associated with decreases in \u2206BMI, \u2206WC and \u2206MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sex\u2010specific associations between the metabolome and change in BC were observed, highlighting metabolic pathways underlying adolescent physical growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12887","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T06:25:04Z","timestamp":1642055104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Metabolomics reveals sex\u2010specific pathways associated with changes in adiposity and muscle mass in a cohort of Mexican adolescents"],"prefix":"10.1111","volume":"17","author":[{"given":"Yanelli","family":"Rodr\u00edguez\u2010Carmona","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-1770","authenticated-orcid":false,"given":"Jennifer L.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Medical School  Ann Arbor Michigan USA"},{"name":"Department of Medicine, Geisel School of Medicine Dartmouth College  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3364-3729","authenticated-orcid":false,"given":"Erica C.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-6850","authenticated-orcid":false,"given":"Wei","family":"Perng","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences University of Michigan School of Public Health  Ann Arbor Michigan USA"},{"name":"Department of Epidemiology and the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health University of Colorado Denver, Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Banker","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter X. 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