{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:52:27Z","timestamp":1760953947754,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A standardized approach for identifying and treating hypothalamic obesity (HO) in children with hypothalamic tumours is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe children with hypothalamic tumours at risk for obesity, assess outcomes of a novel HO clinical algorithm, and identify factors associated with weight gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of youth with hypothalamic and suprasellar tumours, seen at a paediatric tertiary care centre from 2010 to 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a0130, 50% female, median age at diagnosis 5 [range 0\u201317]y) had a median duration of follow up of 5 (0.03\u201317)y. At last recorded body mass index (BMI) measurement, 34% had obesity, including 17% with severe obesity. Median onset of overweight and obesity after diagnosis was 6.2 (0.3\u2013134) and 8.9 (0.7\u201365) months, respectively. After algorithm implementation (<jats:italic>n<\/jats:italic>\u00a0=\u00a013), the proportion that had an early dietitian visit (within 6\u00a0months) increased from 36% to 54%, (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.498) and weight management referrals increased from 51% to 83% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.286). Higher BMI z\u2010score at diagnosis was associated with overweight and obesity development (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with hypothalamic tumours commonly develop obesity. Use of a clinical algorithm may expedite recognition of HO. Further research is needed to identify predictors of weight gain and to develop effective treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12903","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T03:34:00Z","timestamp":1646019240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel clinical algorithm for hypothalamic obesity in youth with brain tumours and factors associated with excess weight gain"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-1950","authenticated-orcid":false,"given":"Amy A.","family":"Rydin","sequence":"first","affiliation":[{"name":"Section of Pediatric Endocrinology, Department of Pediatrics Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Severn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Biostatistics and Informatics Colorado School of Public Health  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Pyle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Biostatistics and Informatics Colorado School of Public Health  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Dorris","sequence":"additional","affiliation":[{"name":"Section of Hematology, Oncology, and Bone Marrow Transplantation, Department of Pediatrics Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Morgan Adams Foundation Pediatric Brain Tumor Research Program, University of Colorado School of Medicine and Children's Hospital Colorado  Aurora Colorado 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