{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:09:17Z","timestamp":1791320957269,"version":"4.3.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Increased intestinal permeability has an important role in metabolic dysregulation. In this cross\u2010sectional study, we examined whether serum intestinal permeability marker zonulin and related pro\u2010inflammatory molecules were associated with the oral disposition index, a predictor for the development of type 2 diabetes, in a cohort of children and adolescents with overweight and obesity. Ninety\u2010two children and adolescents were recruited [Male: 43; 12.7 (2.35) years; BMI SDS: 2.7 (0.96)]. Anthropometric and clinical parameters, lipid profile, glucose metabolism and plasma levels of zonulin, lipopolysaccharide\u2010binding protein and Interleukin\u20106 were measured. We found an association between oral disposition index and zonulin (\u03b2\u00a0=\u00a0\u22120.243; <jats:italic>p<\/jats:italic>\u00a0=\u20090.019) and age (\u03b2\u00a0=\u00a0\u22120.307; <jats:italic>p<\/jats:italic>\u00a0=\u20090.004), independent of sex and BMI SDS [R<jats:sup>2<\/jats:sup>\u00a0=\u20090.16; <jats:italic>p<\/jats:italic>\u00a0=\u20090.005]. Our results show an association between serum zonulin concentration and oral disposition index supporting the hypothesis of increased intestinal permeability as a possible risk factor for glucose metabolism dysregulation in children and adolescents with obesity.<\/jats:p>","DOI":"10.1111\/ijpo.12946","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T08:44:23Z","timestamp":1654505063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Serum zonulin as an index of glucose dysregulation in children and adolescents with overweight and obesity"],"prefix":"10.1111","volume":"17","author":[{"given":"Francesca","family":"Olivieri","sequence":"first","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders, Department of Surgical Sciences, Dentistry, Paediatrics and Gynaecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-2012","authenticated-orcid":false,"given":"Alice","family":"Maguolo","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders, Department of Surgical Sciences, Dentistry, Paediatrics and Gynaecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Corradi","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders, Department of Surgical Sciences, Dentistry, Paediatrics and Gynaecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Zusi","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders, Department of Surgical Sciences, Dentistry, Paediatrics and Gynaecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Huber","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders, Department of Surgical Sciences, Dentistry, Paediatrics and Gynaecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Fornari","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders, Department of Surgical Sciences, Dentistry, Paediatrics and Gynaecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Morandi","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders, Department of Surgical Sciences, Dentistry, Paediatrics and Gynaecology University of Verona  Verona 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