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Anthropometric neonatal data were collected from birth records, whereas breastfeeding practices were reported by parents. A 3.0 Tesla Siemens Magnetom Tim Trio system was used to acquire T1\u2010weighted and resting\u2010state functional magnetic resonance images. Academic performance was assessed by the Woodcock\u2010Mu\u00f1oz standardized test. Hippocampal seed\u2010based methods with post\u2010hoc regression analyses were performed. Analyses were considered significant when surpassing Family\u2010Wise Error corrections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Birth weight showed a positive association with the connectivity between the hippocampus and the pre\u2010 and postcentral gyri, and the cerebellum. In addition, breastfeeding was negatively associated with the connectivity between the hippocampus and the primary motor cortex and the angular gyrus. Any breastfeeding, in turn, showed a positive association with the connectivity between the hippocampus and the middle temporal gyrus. None of the connectivity outcomes related to early life factors was coupled with better academic abilities (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that birth weight at birth and breastfeeding are associated with hippocampal connectivity in children with overweight\/obesity. Despite this, how the results relate to academic performance remains a matter of speculation. Our findings suggest that clinicians should recognize the importance early life factors for potentially avoiding consequences on offspring's brain development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.12998","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T12:24:05Z","timestamp":1672143845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early life factors and hippocampal functional connectivity in children with overweight\/obesity"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-9528","authenticated-orcid":false,"given":"Patricio","family":"Solis\u2010Urra","sequence":"first","affiliation":[{"name":"PROFITH \u201cPROmoting FITness and Health Through Physical Activity\u201d Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences University of 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