{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:24:59Z","timestamp":1756189499341,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M680266","BX20200019"],"award-info":[{"award-number":["2020M680266","BX20200019"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103865"],"award-info":[{"award-number":["82103865"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222244"],"award-info":[{"award-number":["7222244"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Birth weight (BW) and sibling's status are two important indicators of early intrauterine environment and subsequent living environment, but no evidence has emerged on their joint associations on metabolic obesity phenotype. To determine the joint associations between BW and single\u2010child status with childhood metabolic obesity phenotype was our purpose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional assessment of children and adolescents aged 7\u201318\u2009years was performed in Chinese seven provinces in 2013. We obtained anthropometric, blood pressure and biochemical measurements, and distributed questionnaires covering demographic, neonatal and lifestyle characteristics. The metabolic obesity phenotype was defined by 2018 consensus\u2010based criteria. Logistic regression and restricted cubic spline models were applied to evaluate the associations of BW and metabolic obesity phenotype, and estimate the multiplicative interactions and the combined associations of BW and single\u2010child status with metabolic obesity phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of enrolled 12\u2009346 children and adolescents, the prevalence of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) was 1.96% and 3.03%. There were 8.95% and 4.03% children with high BW or low BW, and 67.55% did not have siblings. High BW was positively associated with MHO (OR\u00a0=\u00a01.94, 95%CI\u00a0=\u00a01.28\u20132.94). Single\u2010child also had increased odds of MHO and MUO (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and it had joint associations with high BW showing 0.85\u2010 to 2.58\u2010fold higher odds of MUO and MHO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High BW and single\u2010child status have joint positive associations with the subsequent odds of MHO and MUO, which should be jointly prevented through earlier screening and subsequent preventive strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13021","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T10:11:00Z","timestamp":1678702260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The joint associations of high birth weight and not having siblings with metabolic obesity phenotype among school\u2010aged children and adolescents: A National Survey in China"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6584-1191","authenticated-orcid":false,"given":"Jieyu","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Population Medicine and Public Health Chinese Academy of Medical Sciences\/Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health and Management Ningxia Medical University  Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manman","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjie","family":"Cui","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing Peking University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongjun","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-1808","authenticated-orcid":false,"given":"Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-3200","authenticated-orcid":false,"given":"Yanhui","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Child and Adolescent Health, School of Public Health Peking University, National Health Commission Key Laboratory of Reproductive Health  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000471488"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003351"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12721"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4345"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2021.05.017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1638-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2015.05.011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22391"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3760"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0844-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2017.07.018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.661164"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12963"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000218132.68268.f4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14030500"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nux060"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1516-9"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.615283"},{"issue":"3","key":"e_1_2_9_21_1","first-page":"245","article-title":"Effect of body mass index on all\u2010cause mortality and incidence of cardiovascular diseases\u2010\u2010report for meta\u2010analysis of prospective studies open optimal cut\u2010off points of body mass index in Chinese adults","volume":"15","author":"Zhou B","year":"2002","journal-title":"Biomed Environ Sci"},{"issue":"12","key":"e_1_2_9_22_1","first-page":"1","article-title":"Methodology of the youth risk behavior surveillance system","volume":"53","author":"Brener N","year":"2004","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14010063"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10040451"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-8-115"},{"issue":"6","key":"e_1_2_9_26_1","first-page":"390","article-title":"Report on childhood obesity in China (1)\u2010\u2010body mass index reference for screening overweight and obesity in Chinese school\u2010age children","volume":"18","author":"Ji C","year":"2005","journal-title":"Biomed Environ Sci"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.07.013"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2008.08.003"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.248"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx031"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0436"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2016.07.013"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488595"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08643"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-012-9212-x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.842233"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4493-y"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14414"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.06.005"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2017.07.002"},{"issue":"3","key":"e_1_2_9_41_1","first-page":"A50","article-title":"Family structure and childhood obesity, Early Childhood Longitudinal Study\u2014kindergarten cohort","volume":"7","author":"Chen A","year":"2010","journal-title":"Prev Chronic Dis"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2015.08.003"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15598"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609033354"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2015.05.021"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-766"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-14-124"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19806"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.13021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijpo.13021","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.13021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:24:34Z","timestamp":1692717874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.13021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/ijpo.13021"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.13021","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"type":"print","value":"2047-6302"},{"type":"electronic","value":"2047-6310"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"assertion":[{"value":"2022-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13021"}}