{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:55:55Z","timestamp":1789649755297,"version":"4.0.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["ULI TR001085"],"award-info":[{"award-number":["ULI TR001085"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL096015"],"award-info":[{"award-number":["R01 HL096015"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine changes in leukocyte telomere length (LTL) during and after a behavioural weight control program for children with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured LTL among a cohort of 158 children 8\u201312\u2009years of age with a body mass index greater than or equal to the 95th percentile for age and sex. Children were 55% female, 29% white, 52% Latinx, 8% Asian and 11% Pacific Islander, other or multiethnic. All children participated in a 6\u2010month, family\u2010based, group behavioural weight control program and were assessed before treatment, after treatment and 1\u2009year after the end of treatment. To test the sample population slope of LTL over the intervention and maintenance time periods, we fit spline mixed\u2010effect regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LTL increased an average of 0.09\u2009T\/S\u2009units per year (95% confidence interval [CI] 0.04 to 0.13; <jats:italic>p<\/jats:italic>\u2009=\u20090.0001) during the weight control program intervention period, followed by an average decline of \u22120.05\u2009T\/S\u2009units per year (95% CI \u22120.08 to \u22120.03; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) during the 1\u2009year of follow\u2010up after the completion of the intervention. Among 26 social, psychological, behavioural and physiological factors we examined, we did not find any predictors of these changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LTL increased in response to a behavioural weight control program among children with obesity, suggesting an impact on biological health and cellular aging from participation in a behavioural weight control intervention. LTL may be a useful biomarker for assessing changes in response to behavioural interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13082","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:51:48Z","timestamp":1698144708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in leukocyte telomere length among children with obesity participating in a behavioural weight control program"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-6513","authenticated-orcid":false,"given":"David H.","family":"Rehkopf","sequence":"first","affiliation":[{"name":"Departments of Epidemiology and Population Health, Medicine, Pediatrics and Sociology Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Wojcicki","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Epidemiology and Biostatistics University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Farish","family":"Haydel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher I.","family":"Kapphahn","sequence":"additional","affiliation":[{"name":"Quantitative Sciences Unit Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Medicine and by courtesy Epidemiology and Population Health Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240185"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2528"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.104537"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002188"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21183"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.298"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.4830"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2016.04.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-016-0069-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089828"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450190051027"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.13.5.373"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.58.5.661"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800860"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/chi.2021.0166"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.10.e47"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00395.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101293"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901275R"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020318"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2018.0885"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255484"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.0258"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-016-0420-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4227"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.205492"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0744"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.03.032"}],"container-title":["Pediatric 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