{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:34:46Z","timestamp":1787506486732,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017618","name":"Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["T32 DK007169"],"award-info":[{"award-number":["T32 DK007169"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["RuthL.KirschsteinNationalResearchServiceAward"],"award-info":[{"award-number":["RuthL.KirschsteinNationalResearchServiceAward"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK118403"],"award-info":[{"award-number":["R01DK118403"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1U01DK094830"],"award-info":[{"award-number":["1U01DK094830"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL2TR001422"],"award-info":[{"award-number":["UL2TR001422"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cord blood (CB) leptin is positively associated with adiposity at birth, but the association with child adiposity is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We hypothesized that CB leptin is positively associated with adiposity in peripubertal children and with childhood leptin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Leptin was measured in 986 CB and 931 childhood stored samples from a prospective birth cohort. Adiposity measures were collected at birth and mean age 11.5\u2009years. Linear and logistic regression analyses were used to evaluate associations between log\u2010transformed CB leptin and neonatal and childhood adiposity measures as continuous and categorical variables, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CB leptin was positively associated with neonatal and childhood adiposity. Childhood associations were attenuated when adjusted for maternal body mass index (BMI) and glucose, but remained statistically significant for childhood body fat percentage (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20091.15%, confidence interval [CI]\u2009=\u20090.46\u20131.84), body fat mass (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.69\u2009kg, 95% CI\u2009=\u20090.16\u20131.23), sum of skin\u2010folds (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20091.77\u2009mm, 95% CI\u2009=\u20090.31\u20133.24), log\u2010transformed child serum leptin (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.13, 95% CI\u2009=\u20090.06\u20130.20), overweight\/obesity (OR\u2009=\u20091.21, 95% CI\u2009=\u20091.03\u20131.42), obesity (OR\u2009=\u20091.31, 95% CI\u2009=\u20091.04\u20131.66) and body fat percentage &gt;85th percentile (OR\u2009=\u20091.38, 95% CI\u2009=\u20091.12\u20131.73). Positive associations between newborn adiposity measures and CB leptin confirmed previous reports.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CB leptin is positively associated with neonatal and childhood adiposity and child leptin levels, independent of maternal BMI and maternal hyperglycemia. CB leptin may be a biomarker of future adiposity risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.13087","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T06:52:15Z","timestamp":1702536735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Leptin and adiposity measures from birth to later childhood: Findings from the\n                    <scp>Hyperglycemia and Adverse Pregnancy Outcomes Follow\u2010Up<\/scp>\n                    Study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7955-5732","authenticated-orcid":false,"given":"Sean","family":"DeLacey","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics Ann &amp; Robert H. 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