{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:35:27Z","timestamp":1772271327885,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited research on alanine aminotransferase (ALT) screening for metabolic dysfunction\u2010associated steatotic liver disease (MASLD) among US Asian\/Pacific Islander (PI) children necessitates investigation in this heterogeneous population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Examine ALT elevation among Asian\/PI children with overweight or obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Elevated ALT prevalence (clinical threshold) and association with body mass index \u226585th percentile were compared among 18\u2009402 Asian\/PI and 25\u2009376 non\u2010Hispanic White (NHW) children aged 9\u201317\u2009years using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ALT elevation was more prevalent among Asian\/PI (vs. NHW) males with overweight (4.0% vs. 2.7%), moderate (7.8% vs. 5.3%) and severe obesity (16.6% vs. 11.5%), and females with moderate (5.1% vs. 3.0%) and severe obesity (10.2% vs. 5.2%). Adjusted odds of elevated ALT were 1.6\u2010fold and ~2\u2010fold higher for Asian\/PI (vs. NHW) males and females (with obesity), respectively. Filipino, Chinese and Southeast Asian males had 1.7\u20132.1\u2010fold higher odds, but Native Hawaiian\/PI (NHPI) and South Asian males did not significantly differ (vs. NHW). Filipina and Chinese females with obesity had &gt;2\u2010fold higher odds, Southeast and South Asian females did not differ and NHPI findings were mixed (vs. NHW).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High elevated ALT prevalence among Asian\/PI children with overweight and obesity emphasizes the need for MASLD risk assessment and examination of ethnic subgroups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13110","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T07:09:45Z","timestamp":1709708985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Alanine aminotransferase elevation varies by ethnicity among Asian and Pacific Islander children with overweight or obesity"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-9052","authenticated-orcid":false,"given":"Catherine","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland California USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine  Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-2877","authenticated-orcid":false,"given":"Jeffrey B.","family":"Schwimmer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition University of California San Diego School of Medicine  San Diego California USA"},{"name":"Department of Gastroenterology Rady Children's Hospital  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-1964","authenticated-orcid":false,"given":"Erica P.","family":"Gunderson","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland California USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine  Pasadena California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi P.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition University of California San Diego School of Medicine  San Diego California USA"},{"name":"Department of Gastroenterology Rady Children's Hospital  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne A.","family":"Darbinian","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise C.","family":"Greenspan","sequence":"additional","affiliation":[{"name":"The Permanente Medical Group  Oakland California USA"},{"name":"Department of Pediatrics, Division of Pediatric Endocrinology Kaiser Permanente San Francisco Medical Center  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-0648","authenticated-orcid":false,"given":"Joan C.","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland California USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. 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