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Moderate certainty evidence demonstrated a \u22121.71 (95% confidence interval [CI]: \u22122.27 to \u22121.14)\u2010unit BMI reduction, ranging from \u22120.8 to \u22125.9\u2009units between individual drugs with semaglutide producing the largest reduction of \u22125.88\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (95% CI: \u22126.99 to \u22124.77,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009201). Drug type explained ~44% of heterogeneity. Low certainty evidence demonstrated reduction in 95th percentile BMI: \u221211.88 percentage points (95% CI: \u221218.43 to \u22125.30,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009668). Serious adverse events and study discontinuation due to adverse events did not differ between medications and comparators, but medication dose adjustments were higher compared to comparator (10.6% vs 1.7%; RR\u2009=\u20093.74 [95% CI: 1.51 to 9.26],\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200915%), regardless of approval status. There was a trend towards improved quality of life. Evidence gaps exist for children, psychosocial outcomes, comorbidities and weight loss maintenance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>Anti\u2010obesity medications in addition to behaviour change improve BMI but may require dose adjustment, with 1 in 100 adolescents experiencing a serious adverse event.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.13113","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T01:58:39Z","timestamp":1709863119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pharmacological interventions for the management of children and adolescents living with obesity\u2014An update of a Cochrane systematic review with 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