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Previous neuroimaging studies suggest that T2\u2010based signal properties indicative of cellular inflammatory response (gliosis) are present in adults and children with obesity, and predicts greater adiposity gain in children at risk of obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives\/Methods<\/jats:title><jats:p>The current study aimed to extend this concept to the early life period by considering if, in full\u2010term healthy neonates (up to <jats:italic>n<\/jats:italic> =\u200935), MRI evidence of MBH gliosis is associated with changes in early life (neonatal to six months) body fat percentage measured by DXA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this initial study, neonatal T2 signal in the MBH was positively associated with six\u2010month changes in body fat percentage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This finding supports the notion that underlying processes in the MBH may play a role in early life growth and, by extension, childhood obesity risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13114","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T09:49:50Z","timestamp":1710323390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations of radiologic characteristics of the neonatal hypothalamus with early life adiposity gain"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-9499","authenticated-orcid":false,"given":"Leticia E.","family":"Sewaybricker","sequence":"first","affiliation":[{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan J.","family":"Melhorn","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Entringer","sequence":"additional","affiliation":[{"name":"Development, Health and Disease Research Program University of California  Irvine California USA"},{"name":"Department of Pediatrics University of California  Irvine California USA"},{"name":"Department of Medical Psychology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Buss","sequence":"additional","affiliation":[{"name":"Development, Health and Disease Research Program University of California  Irvine California USA"},{"name":"Department of Pediatrics University of California  Irvine California USA"},{"name":"Department of Medical Psychology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pathik D.","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Development, Health and Disease Research Program University of California  Irvine California USA"},{"name":"Department of Pediatrics University of California  Irvine California USA"},{"name":"Department of Obstetrics and Gynecology University of California  Irvine California USA"},{"name":"Department of Psychiatry and Human Behavior University of California  Irvine California USA"},{"name":"Department of Epidemiology University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen A.","family":"Schur","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerod 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