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Cardiometabolic risk factors (i.e., BMI, blood pressure, lipids, blood sugar, C\u2010reactive protein) were measured at the final timepoint when children were 7\u201311\u2009years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In adjusted logistic regression models, greater cumulative environmental stress was associated with a higher likelihood of elevated cardiometabolic risk in middle childhood (<jats:italic>p<\/jats:italic>\u2009=\u20090.01). Children from minoritized racial\/ethnic groups had a higher prevalence of both stressors and cardiometabolic risk factors. Cumulative environmental stress was associated with higher hair cortisol concentrations (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). However, hair cortisol was not directly associated with cardiometabolic risk factors and did not explain the association between environmental stress and cardiometabolic risk in causal mediation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The influence of cumulative stress on cardiometabolic health can be observed in middle childhood and may contribute to cardiometabolic health disparities, highlighting the importance of public health interventions to mitigate disadvantage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13116","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T06:04:46Z","timestamp":1711692286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cumulative environmental stress and emerging cardiometabolic risk during childhood"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-5602","authenticated-orcid":false,"given":"Alicia S.","family":"Kunin\u2010Batson","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Center for Pediatric Obesity Medicine University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Haapala","sequence":"additional","affiliation":[{"name":"HealthPartners Institute  Bloomington Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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