{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:45:22Z","timestamp":1757778322210,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Resting energy expenditure (REE) assessments can help inform clinical treatment decisions in adolescents with elevated body mass index (BMI), but current equations are suboptimal for severe obesity. We developed a predictive REE equation for youth with severe obesity and obesity\u2010related comorbidities and compared results to previously published predictive equations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from indirect calorimetry, clinical measures, and body composition per Dual x\u2010ray absorptiometry (DXA) were collected from five sites. Data were randomly divided into development (<jats:italic>N<\/jats:italic>\u2009=\u2009438) and validation (<jats:italic>N<\/jats:italic>\u2009=\u2009118) cohorts. A predictive equation was developed using Elastic Net regression, using sex, race, ethnicity, weight, height, BMI percent of the 95th%ile (BMIp95), waist circumference, hip circumference, waist\/hip ratio, age, Tanner stage, fat and fat\u2010free mass. This equation was verified in the validation cohort and compared with 11 prior equations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from the total cohort (<jats:italic>n<\/jats:italic>\u2009=\u2009556, age 15\u2009\u00b1\u20091.7\u2009years, 77% female, BMIp95 3.3\u2009\u00b1\u20090.94) were utilized. The best fit equation was REE\u2009=\u2009\u22122048\u2009+\u200918.17 \u00d7 (Height in cm) \u2013 2.57 \u00d7 (Weight in kg)\u2009+\u20097.88 \u00d7 (BMIp95)\u2009+\u2009189 \u00d7 (1\u2009=\u2009male, 0\u2009=\u2009female), <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.466, and mean bias of 23\u2009kcal\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This new equation provides an updated REE prediction that accounts for severe obesity and metabolic complications frequently observed in contemporary youth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13123","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T03:09:28Z","timestamp":1714014568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prediction of resting energy expenditure for adolescents with severe obesity: A multi\u2010centre analysis"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-1950","authenticated-orcid":false,"given":"Amy A.","family":"Rydin","sequence":"first","affiliation":[{"name":"Section of Pediatric Endocrinology, Department of Pediatrics Children's Hospital Colorado, University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Severn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Biostatistics and Informatics Colorado School of Public Health  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Pyle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Biostatistics and Informatics Colorado School of Public Health  Aurora 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Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack A.","family":"Yanovski","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan C.","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Mount Sinai Kravis Children's Hospital Icahn School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine A.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Section of Pediatric Endocrinology, Department of Pediatrics Children's Hospital Colorado, University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Section of Nutrition, Department of 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