{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:29:19Z","timestamp":1788809359907,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002494"],"award-info":[{"award-number":["UL1TR002494"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["K23DK125668"],"award-info":[{"award-number":["K23DK125668"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anti\u2010obesity medications (AOMs) are promising lifestyle modification (LSM) adjuncts for obesity treatment, and phentermine is commonly prescribed in paediatric weight management clinics. Determining \u2018real\u2010world\u2019 AOM effectiveness and characteristics predicting response is important.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to describe phentermine plus LSM effectiveness and identify baseline characteristics predicting response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study among youth seen in a US academic\u2010based weight management clinic from 2012 to 2020. Baseline characteristics (e.g., body mass index (BMI), liver transaminases, eating\u2010related behaviours) and outcomes (%BMI of 95th percentile (%BMIp95), BMI, %BMI change, weight) were determined through electronic health records and intake surveys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 91 youth prescribed phentermine plus LSM over 8\u2009years (mean %BMIp95 150%), %BMIp95 was statistically significantly reduced at 1.5, 3, 6 and 12\u2009months (peak reduction 10.9 percentage points at 6\u2009months; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Considering multiple comparisons, the presence of baseline elevated alanine aminotransferase was associated with statistically significant smaller 1.5\u2010month %BMIp95 reductions (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and higher food responsiveness with smaller 3\u2010 (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and 6\u2010month (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) reductions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Phentermine plus LSM reduced %BMIp95 among youth in a weight management clinic, and baseline characteristics may help determine those more or less likely to respond. Prospective studies are needed to further characterize effectiveness and confirm response predictors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13143","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T04:45:51Z","timestamp":1718685951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness and predictors of weight loss response to phentermine plus lifestyle modifications among youth in a paediatric weight management clinical setting"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-4314","authenticated-orcid":false,"given":"Eric M.","family":"Bomberg","sequence":"first","affiliation":[{"name":"Center for Pediatric Obesity Medicine, Department of Pediatrics, Medical School University of Minnesota  Minneapolis Minnesota USA"},{"name":"Department of Pediatrics, Medical School University of Minnesota  Minneapolis Minnesota 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