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Adiponectin, C\u2010reactive protein, epidermal growth factor, insulin\u2010like growth factor\u20101, interleukin (IL)\u20101\u03b2, IL\u20106, leptin, tumour necrosis factor\u2010\u03b1 and vascular endothelial growth factor A (VEGFA) were analysed in plasma. Total white blood cell (WBC) count and immune subpopulations (eosinophils, basophils, neutrophils, lymphocytes and monocytes) were also determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No intervention effect was found for any of the analysed biomarkers (all <jats:italic>p<\/jats:italic>\u2009\u2265\u20090.05). We observed a significant sex by intervention interaction for IL\u20101\u03b2 (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). When stratifying the sample by sex, the exercise programme induced a significant effect on IL\u20101\u03b2 levels (mean <jats:italic>Z<\/jats:italic>\u2010score difference, 0.66 [95% confidence interval 0.32\u20131.01]) in girls, but not in boys. A lower number of girls in the exercise group showed a meaningful reduction in IL\u20101\u03b2 (i.e., \u22650.2 standard deviations) than in the control group (15% vs. 85%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This exercise programme failed to improve the inflammatory profile in prepubertal children with overweight\/obesity. Future studies should explore the effect of longer exercise interventions and in combination with diet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13152","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T05:54:43Z","timestamp":1722491683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of combined aerobic and resistance training on the inflammatory profile of children with overweight\/obesity: A randomized clinical trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-876X","authenticated-orcid":false,"given":"Jose J.","family":"Gil\u2010Cosano","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"Department of Health Sciences and Biomedicine, Faculty of Health Sciences Universidad Loyola Andaluc\u00eda  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-3129","authenticated-orcid":false,"given":"Abel","family":"Plaza\u2010Florido","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine University of California at Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4020-0256","authenticated-orcid":false,"given":"Luis","family":"Gracia\u2010Marco","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria, ibs.Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0366-6935","authenticated-orcid":false,"given":"Jairo H.","family":"Migueles","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-9108","authenticated-orcid":false,"given":"Cristina","family":"Cadenas\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Cardiology, Stanford &amp; 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