{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:37:35Z","timestamp":1785893855026,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000124","name":"Office of Research on Women's Health","doi-asserted-by":"publisher","award":["731903"],"award-info":[{"award-number":["731903"]}],"id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Up to 50% of adolescents who undergo metabolic and bariatric surgery (MBS) have obesity 3\u2009years post\u2010MBS, placing them at continued risk for the consequences of obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We conducted an open\u2010label, 16\u2010week pilot study of liraglutide in adolescents with obesity after sleeve gastrectomy (SG) to investigate liraglutide effects on weight and body mass index (BMI) post\u2010SG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adolescents aged 12\u201320.99\u2009years with obesity and a history of SG \u22651 year prior were enrolled. Liraglutide was initiated at 0.6\u2009mg\/day, escalated weekly to a maximum of 3\u2009mg\/day, with treatment duration 16\u2009weeks. Fasting laboratory assessments and an oral glucose tolerance test were performed at baseline and end\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 43 participants were screened, 34 initiated liraglutide (baseline BMI 41.2\u2009\u00b1\u20097.7\u2009kg\/m<jats:sup>2<\/jats:sup>), and 31 (91%) attended the end\u2010treatment visit. BMI decreased by 4.3% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) with liraglutide. Adolescents who had poor initial response to SG (&lt;20% BMI reduction at BMI nadir) had less weight loss with liraglutide. Fasting glucose and haemoglobin A1C concentrations significantly decreased. There were no serious treatment\u2010emergent adverse events reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Liraglutide treatment was feasible and associated with a BMI reduction of 4.3% in adolescents who had previously undergone SG, quantitatively similar to results obtained in adolescents with obesity who have not undergone MBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13154","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:46:47Z","timestamp":1722908807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An open\u2010label 16\u2010week study of liraglutide in adolescents with obesity post\u2010sleeve gastrectomy"],"prefix":"10.1111","volume":"19","author":[{"given":"Anna","family":"Zenno","sequence":"first","affiliation":[{"name":"Section on Growth and Obesity, Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda Maryland USA"},{"name":"Department of Pediatrics University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ejike E.","family":"Nwosu","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Z.","family":"Fatima","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan P.","family":"Nadler","sequence":"additional","affiliation":[{"name":"Children's National Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazrat M.","family":"Mirza","sequence":"additional","affiliation":[{"name":"Children's National Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila M.","family":"Brady","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Turner","sequence":"additional","affiliation":[{"name":"Nutrition Department Clinical Center, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanna B.","family":"Yang","sequence":"additional","affiliation":[{"name":"Nutrition Department Clinical Center, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Lazareva","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Te\u2010Vasquez","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kong Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6989-0417","authenticated-orcid":false,"given":"Stephanie T.","family":"Chung","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8542-1637","authenticated-orcid":false,"given":"Jack A.","family":"Yanovski","sequence":"additional","affiliation":[{"name":"Section on Growth and Obesity, Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)  Bethesda Maryland 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