{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:35:02Z","timestamp":1792794902099,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dietary interventions and increased physical activity are the cornerstones for management of the paediatric non\u2010alcoholic fatty liver disease (NAFLD). Though, no specific diet has been proven superior, Indo\u2010Mediterranean diet (IMD) has shown promise in adult literature. Thus, we aimed to compare the effect of IMD and a standard calorie\u2010restricted diet (CRD) in Indian overweight children and adolescents with biopsy\u2010proven NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010nine consecutive biopsy\u2010proven NAFLD children between the ages of 8 and 18\u2009years were randomized into either IMD or CRD for 180\u2009days, and various parameters were evaluated at baseline and then after 180\u2009days (NCT05073588).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 34 subjects (18 in IMD and 16 in CRD group) completed the study. There was a significantly higher decrease in controlled attenuation parameter (CAP) values (as a marker of hepatic steatosis; on transient elastography) (95% CI: 4.2\u201373.4, <jats:italic>p<\/jats:italic>\u2009=\u20090.042), weight (95% CI: 0.75\u20135.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.046) and body mass index (BMI) (95% CI: 0.21\u20132.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.014) (but not in Pediatric NAFLD Fibrosis Index or PNFI; as a marker of hepatic fibrosis) in IMD group compared to the CRD group. Liver stiffness measurement, serum cholesterol and low\u2010density lipoprotein levels and HOMA\u2010IR decreased only in the IMD group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Our statistical model showed that delta\u2010Weight was the only independent variable associated with delta\u2010CAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both IMD and CRD can improve the various anthropometric, clinical, imaging and biochemical parameters but IMD was superior to CRD in terms of reducing CAP values and weight\/BMI over 180\u2009days in overweight\/obese NAFLD children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13163","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T06:50:45Z","timestamp":1725346245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect <scp>of Indo<\/scp>\u2010Mediterranean diet versus calorie\u2010restricted diet in children with non\u2010alcoholic fatty liver disease: A pilot randomized control trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-6462","authenticated-orcid":false,"given":"Aniket","family":"Deshmukh","sequence":"first","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikrant","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikrant Bihari","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-8625","authenticated-orcid":false,"given":"Seema","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.21"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2018.05.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2017.02.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001386"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2021.11.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001482"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11472-3"},{"key":"e_1_2_6_11_1","unstructured":"National Institute of Nutrition Indian Council of Medical Research Department of Health Research Ministry of Health and Family Welfare Government of India.Nutrient requirements for Indians: recommended dietary allowances & estimated average requirements for Indians \u2013 2020. 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