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Maternal prenatal psychobiological risk (PPBR) was assessed during the third trimester via maternal anthropometrics, serum biomarkers (insulin, leptin, adiponectin), and maternal report of pregnancy complications, substance use, mental health and stress. Infant stress reactivity was measured at 2\u2009months (cortisol output, resting RSA, observed irritability, negative emotionality). At 2 and 6\u2009months, maternal self\u2010report of obesogenic feeding practices and observed maternal sensitivity during three tasks were collected. RWG was classified based on change in weight\u2010for\u2010age z scores from birth to 6\u2009months (&gt;0.67 SD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Obesogenic feeding practices predicted greater likelihood of RWG, <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.30, <jats:italic>p<\/jats:italic>\u2009=\u2009.0.01, independent of other predictors and covariates. Obesogenic feeding practices was the only proposed intervening mechanism that produced a significant indirect effect of PPBR on RWG, <jats:italic>b<\/jats:italic>\u2009=\u20090.05, S.E. =\u20090.04, 95% CI [0.002, 0.15], <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.06.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Identifying proclivity towards obesogenic feeding practices and providing support to reduce these behaviours may enhance childhood obesity prevention efforts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13170","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:59:17Z","timestamp":1724979557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biopsychosocial predictors of rapid weight gain from birth to 6\u2009months"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-6452","authenticated-orcid":false,"given":"Esther M.","family":"Leerkes","sequence":"first","affiliation":[{"name":"Department of Human Development and Family Studies UNC Greensboro  Greensboro North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Buehler","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies UNC Greensboro  Greensboro North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Wideman","sequence":"additional","affiliation":[{"name":"Department of Kinesiology UNC Greensboro  Greensboro North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Human Development and Family Studies UNC Greensboro  Greensboro North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenka H.","family":"Shriver","sequence":"additional","affiliation":[{"name":"Department of Nutrition UNC Greensboro  Greensboro North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Obesity and Overweight.2024. 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