{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:14:50Z","timestamp":1787624090111,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["ADA\u20107\u201022\u2010ICTSPM\u201008"],"award-info":[{"award-number":["ADA\u20107\u201022\u2010ICTSPM\u201008"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 DK134981"],"award-info":[{"award-number":["U01 DK134981"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH3OD023248"],"award-info":[{"award-number":["UH3OD023248"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the predictive potential of the in utero exposome in relation to childhood adiposity as indicated by body mass index z\u2010scores (<jats:styled-content style=\"fixed-case\">BMIz<\/jats:styled-content>) and the fourth versus first quartile of % fat mass (<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>) at median age of 4.6\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We leveraged data on clinical risk factors for childhood obesity during the perinatal period, along with cord blood per\/polyfluoroalkyl substances (<jats:styled-content style=\"fixed-case\">PFAS<\/jats:styled-content>) and cord blood <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation, in 268 mother\u2013offspring pairs. We used the sparsity ranked <jats:styled-content style=\"fixed-case\">LASSO<\/jats:styled-content> penalized regression framework for each outcome and assessed model performance based on % variability explained for <jats:styled-content style=\"fixed-case\">BMIz<\/jats:styled-content> and area under the receiver operating characteristic curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) for the fourth versus first quartile of %<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>. We employed cross\u2010validation for model tuning and split\u2010sample validation for model evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean\u2009\u00b1\u2009<jats:styled-content style=\"fixed-case\">SD BMIz<\/jats:styled-content> was 0.01\u2009\u00b1\u20091.1, %<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> was 19.8\u2009\u00b1\u20096.34%. The optimal model for predicting <jats:styled-content style=\"fixed-case\">BMIz<\/jats:styled-content> explained 19.1% of the variability in the validation set and included only clinical characteristics: maternal pre\u2010pregnancy <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, paternal <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, gestational weight gain, physical activity during pregnancy and child race\/ethnicity. The optimal model for fourth versus first quartiles of %<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> achieved an <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> of 0.82\u2009\u00b1\u20090.01 in the validation set, with the clinical features again emerging as the strongest predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study sample, perinatal chemical exposures and the epigenome have low utility in predicting childhood adiposity, beyond known clinical risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13172","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T06:56:17Z","timestamp":1727420177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The predictive utility of the in utero exposome for childhood adiposity in independent and integrated frameworks"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0389-0020","authenticated-orcid":false,"given":"Jonathan","family":"VanHawkins","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Informatics, Colorado School of Public Health University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics, Colorado School of Public Health University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Harrall","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandy","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Dabelea","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Kechris","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics, Colorado School of Public Health University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-6850","authenticated-orcid":false,"given":"Wei","family":"Perng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3201"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000135998.08025.FB"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/inthealth\/ihy006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010019\u20104914\u20101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0456"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr236"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp5975"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.094946"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010021\u201005533\u20100"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000000373"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/whr.2022.0011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.104983"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2023.02.004"},{"key":"e_1_2_8_15_1","first-page":"1","article-title":"2000 CDC growth charts for the United States: methods and development","volume":"246","author":"Kuczmarski RJ","year":"2002","journal-title":"Vital Health Stat 11"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602090"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10182\u2010021\u201000431\u20107"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105622"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572\u2010022\u201000387\u2010z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12902"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.13172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T02:05:23Z","timestamp":1731031523000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.13172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,26]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/ijpo.13172"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.13172","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"value":"2047-6302","type":"print"},{"value":"2047-6310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,26]]},"assertion":[{"value":"2023-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13172"}}