{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:19:11Z","timestamp":1787681951802,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK129656"],"award-info":[{"award-number":["R01DK129656"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54GM104938"],"award-info":[{"award-number":["U54GM104938"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001298","name":"Presbyterian Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001298","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is increasingly common in the pediatric population and may increase risk for developing cardiovascular disease (CVD) in people with MASLD. Oxidized high\u2010density lipoprotein (oxHDL) and oxidized low\u2010density lipoprotein (oxLDL) are modified, pro\u2010atherosclerotic lipoproteins that are increased in adults with MASLD and CVD but have not been reported in adolescents with MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine if oxLDL and oxHDL are increased in adolescents with MASLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fasting oxHDL and oxLDL were measured in adolescents (11\u201320\u2009years) with obesity and biopsy\u2010confirmed MASLD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200947), and peers without MASLD but with obesity (Ob;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928), or normal weight (NW;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      oxHDL was 27% higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in the MASLD group (mean\u2009\u00b1\u2009SD: 11.9\u2009\u00b1\u20094.7\u2009ng\/mL) compared to the Ob group (9.3\u2009\u00b1\u20093.7\u2009ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) but only 7% higher than the NW group (11.1\u2009\u00b1\u20093.8\u2009ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). However, HDL\u2010C was 19% and 32% lower in the MASLD group than in the Ob and NW groups, respectively. Thus, oxHDL\/HDL\u2010C ratio was 55% and 66% higher in MASLD compared to the Ob group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.004) and the NW group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), respectively. oxLDL (52.4\u2009\u00b1\u200916.0, 46.7\u2009\u00b1\u200910.1 and 47.1\u2009\u00b1\u200915.2\u2009U\/L for MASLD, Ob and NW, respectively), LDL\u2010C and the oxLDL\/LDL\u2010C ratio did not differ among groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The elevated oxHDL and oxHDL\/HDL\u2010C in adolescents with MASLD compared to peers with Ob or NW suggests that there is some oxidative stress in MASLD independent of obesity and potential for increased CVD risk in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.13194","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T03:47:32Z","timestamp":1734320852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oxidized high\u2010density lipoprotein and low\u2010density lipoprotein in adolescents with obesity and metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Alyssa M.","family":"Bartlett","sequence":"first","affiliation":[{"name":"Section of Diabetes and Endocrinology, Department of Pediatrics University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M.","family":"Boone","sequence":"additional","affiliation":[{"name":"Section of Diabetes and Endocrinology, Department of Pediatrics University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan A.","family":"Bays","sequence":"additional","affiliation":[{"name":"Section of Diabetes and Endocrinology, Department of Pediatrics University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsil","family":"Kim","sequence":"additional","affiliation":[{"name":"Section of Diabetes and Endocrinology, Department of Pediatrics University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirish K.","family":"Palle","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology &amp; 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