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SDB was assessed using a scale of the reduce version of the Paediatric Sleep Questionnaire. Cardiometabolic markers included fasting blood lipids biomarkers (i.e., low\u2010 and high\u2010density lipoprotein cholesterol, and triglycerides), blood pressure, insulin, glucose, and the homeostatic model assessment index. Inflammatory markers (i.e., interleukin\u20106, interleukin\u20101\u03b2, C\u2010reactive protein [CRP], and tumour necrosis factor alpha) were analysed. Cardiorespiratory fitness was assessed by the 20\u2009m shuttle\u2010run test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant associations were found between SDB severity and most of the cardiometabolic markers after correcting for adiposity and multiple comparisons (all <jats:italic>p<\/jats:italic>'s\u2009&gt;0.05). SDB severity was positively related to CRP (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.352, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), yet not with the remaining inflammatory markers analysed. The interaction effect of cardiorespiratory fitness presented a positive trend in the association of SDB with CRP (<jats:italic>p<\/jats:italic>\u2009=\u20090.1). When stratified analyses by cardiorespiratory fitness levels were conducted, a positive relation was found between SDB and CRP in the low cardiorespiratory fitness group (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.465, <jats:italic>p<\/jats:italic>\u2009=\u20090.014), but not in the high cardiorespiratory fitness group (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.236, <jats:italic>p<\/jats:italic>\u2009=\u20090.108).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SDB severity was positively associated with CRP independently of the adiposity levels, but not with other inflammatory or cardiometabolic risk factors in children with overweight\/obesity. Moreover, our results suggest that higher levels of cardiorespiratory fitness may attenuate the adverse effect of SDB severity on systematic inflammation in children with overweight\/obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.13207","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T10:55:21Z","timestamp":1737456921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sleep\u2010disordered breathing and cardiometabolic and inflammatory markers in children with overweight\/obesity: The role of cardiorespiratory fitness"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-987X","authenticated-orcid":false,"given":"Lucia V.","family":"Torres\u2010Lopez","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences Sport and Health University Research Institute (iMUDS), University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-3129","authenticated-orcid":false,"given":"Abel","family":"Plaza\u2010Florido","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences Sport and Health University Research Institute (iMUDS), University of Granada  Granada Spain"},{"name":"Pediatric Exercise and Genomics Research Center, Department of Pediatrics School of Medicine, University of California at Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J.","family":"Gil\u2010Cosano","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences Sport and Health University Research Institute (iMUDS), University of Granada  Granada Spain"},{"name":"Department of Biological and Health Sciences, Faculty of Health Sciences Universidad Loyola Andaluc\u00eda  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo H.","family":"Migueles","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences Sport and Health University Research Institute (iMUDS), University of Granada  Granada Spain"},{"name":"Department of Biosciences and Nutrition Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco B.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences Sport and Health University Research Institute (iMUDS), University of Granada  Granada Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III  Madrid Spain"},{"name":"Faculty of Sport and Health Sciences University of Jyv\u00e4skyl\u00e4  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