{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:47Z","timestamp":1787014367011,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T00:00:00Z","timestamp":1403568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Fructose intake is associated with non\u2010alcoholic fatty liver disease (\n NAFLD<\/jats:styled-content>\n ) development.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The objective of this study was to measure fructose absorption\/metabolism in paediatric\n NAFLD<\/jats:styled-content>\n compared with obese and lean controls.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Children with histologically proven\n NAFLD<\/jats:styled-content>\n , and obese and lean controls received oral fructose (1\u2009g\u2009kg\n \u22121<\/jats:sup>\n ideal body weight). Serum glucose, insulin, uric acid, and fructose, urine uric acid, urine fructose, and breath hydrogen levels were measured at baseline and multiple points until 360\u2009min after fructose ingestion.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Nine\n NAFLD<\/jats:styled-content>\n (89% Hispanic, mean age 14.3 years, mean body mass index [\n BMI<\/jats:styled-content>\n ] 35.3\u2009kg\u2009m\n \u22122<\/jats:sup>\n ), six obese controls (67% Hispanic, mean age 12.7 years, mean\n BMI<\/jats:styled-content>\n 31.0\u2009kg\u2009m\n \u22122<\/jats:sup>\n ) and nine lean controls (44% Hispanic, mean age 14.3 years, mean\n BMI<\/jats:styled-content>\n 19.4\u2009kg\u2009m\n \u22122<\/jats:sup>\n ) were enrolled. Following fructose ingestion,\n NAFLD<\/jats:styled-content>\n vs. lean controls had elevated serum glucose, insulin and uric acid (\n P<\/jats:italic>\n \u2009<\u20090.05), higher urine uric acid (\n P<\/jats:italic>\n \u2009=\u20090.001), but lower fructose excretion (\n P<\/jats:italic>\n \u2009=\u20090.002) and lower breath hydrogen 180\u2010min\n AUC<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.04).\n NAFLD<\/jats:styled-content>\n vs. obese controls had similar post\u2010fructose serum glucose, insulin, urine uric acid and breath hydrogen, but elevated serum uric acid (\n P<\/jats:italic>\n \u2009<\u20090.05) and lower urine fructose excretion (\n P<\/jats:italic>\n \u2009=\u20090.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Children with\n NAFLD<\/jats:styled-content>\n absorb and metabolize fructose more effectively than lean subjects, associated with an exacerbated metabolic profile following fructose ingestion.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijpo.238","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T12:52:49Z","timestamp":1403614369000},"page":"188-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Oral fructose absorption in obese children with non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"10","author":[{"given":"J. S.","family":"Sullivan","sequence":"first","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Digestive Health Institute Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Le","sequence":"additional","affiliation":[{"name":"Section of Nephrology Department of Medicine University of Colorado Hospital University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics Colorado School of Public Health Aurora CO USA"},{"name":"Colorado Clinical and Translational Sciences Institute University of Colorado Denver Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rivard","sequence":"additional","affiliation":[{"name":"Section of Nephrology Department of Medicine University of Colorado Hospital University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Love\u2010Osborne","sequence":"additional","affiliation":[{"name":"Section of Adolescent Medicine Department of Pediatrics University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Digestive Health Institute Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Section of Nephrology Department of Medicine University of Colorado Hospital University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Sokol","sequence":"additional","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Digestive Health Institute Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"},{"name":"Colorado Clinical and Translational Sciences Institute University of Colorado Denver Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Section of Pediatric Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Digestive Health Institute Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1212"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.01.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.01.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.17.1659"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23535"},{"key":"e_1_2_9_8_1","first-page":"1","article-title":"Fructose: metabolism 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