{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:12Z","timestamp":1787014332638,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To date, research on the natural history of hyperphagia, weight gain and health outcomes in individuals with Bardet\u2010Biedl syndrome (BBS) has been limited. Understanding these characteristics is important for disease burden management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The international Clinical Registry Investigating BBS (CRIBBS) is a registry of individuals with BBS to investigate the severity of hyperphagia, the natural history of weight gain and the frequency of obesity\u2010associated health outcomes in paediatric individuals with BBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Paediatric participants (&lt;18\u2009years of age) enrolled in CRIBBS were evaluated to assess weight and weight loss interventions, hyperphagia and the frequency of cardiac, endocrine\/diabetic and renal health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 331 children, 81.0% had obesity at baseline and 22.7% reported use of weight loss diet or medication at baseline or later. Among participants with \u22652 weight measurements \u22652\u2009years apart (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009186), 17.2% had a higher weight classification from the first to the last assessment. Increasing hyperphagia severity was associated with increasing obesity. The prevalence of cardiac, diabetic, endocrine and renal health outcomes increased with obesity class.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hyperphagia and obesity are highly prevalent in children with BBS. Many children with BBS also experience adverse health outcomes. Timely diagnosis and targeted treatment of hyperphagia and obesity are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.70026","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T21:03:37Z","timestamp":1748898217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical burden of hyperphagia, obesity and health outcomes in paediatric individuals with Bardet\u2010Biedl syndrome: A\n                    <scp>CRIBBS<\/scp>\n                    data analysis"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-9981","authenticated-orcid":false,"given":"Jeremy","family":"Pomeroy","sequence":"first","affiliation":[{"name":"Fritz Wenzel Center for Clinical Research, Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzoma","family":"Okorie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse G.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Office of Research Computing &amp; Analytics, Marshfield Clinic Research Institute  Marshfield Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Faucher","sequence":"additional","affiliation":[{"name":"STATLOG Inc.  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