{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:00:04Z","timestamp":1773248404545,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Visceral fat accumulation causes a low\u2010grade chronic inflammatory state in individuals with Metabolic Syndrome (MetS). MetS detection, with simple and non\u2010invasive tests, is crucial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish the sensitivity and specificity of the monocyte\/HDL (MHR), neutrophils\/lymphocytes (NLR), platelets\/lymphocytes (PLR) and lymphocytes\/monocytes (LMR) ratios to identify clinical characteristics of MetS in prepubertal children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective cross\u2010sectional study comparing 79 children fulfilling MetS IDF criteria and 75 control children. A clinical history and physical examination were performed. Blood glucose levels, lipid profile, ESR, usCRP, and complete blood count were determined, and the different ratios were calculated manually. The sensitivity and specificity of each ratio were determined using ROC curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MHR was the most sensitive and specific haematological index to determine clinical characteristics of MetS with a cut\u2010off point of 8.62, allowing for the identification of low HDL, hypertriglyceridemia, large waist circumference, high blood pressure, sedentary lifestyle, and a family history of obesity as the main factors related to MetS in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MHR is the best proxy of MetS and reveals the early elevation of proinflammatory factors in childhood, suggesting that it serves as a diagnostic tool in patients under 10\u2009years of age, where the identification of MetS is controversial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijpo.70040","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:33:59Z","timestamp":1752075239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identifying Children With Obesity at High Risk for Metabolic Syndrome: Sensitivity and Specificity of the Monocyte\/<scp>HDL<\/scp> Index"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3943-5020","authenticated-orcid":false,"given":"Juan Pablo","family":"Rojas","sequence":"first","affiliation":[{"name":"Institute of Maternal and Child Research Faculty of Medicine, University of Chile  Santiago Chile"},{"name":"San Borja\u2010Arriar\u00e1n Clinical Hospital  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Robles","sequence":"additional","affiliation":[{"name":"Institute of Maternal and Child 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