{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T07:41:25Z","timestamp":1762414885231,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["OHF69442","NMD\u201094067","MOP\u201097853","MOP\u2010119512"],"award-info":[{"award-number":["OHF69442","NMD\u201094067","MOP\u201097853","MOP\u2010119512"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["PG\u2010040291"],"award-info":[{"award-number":["PG\u2010040291"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005242","name":"Universit\u00e9 de Montr\u00e9al","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A dual\u2010energy x\u2010ray absorptiometry (DXA)\u2010derived phenotype classification based on fat mass and muscle mass has been developed for adults. We extended this to a paediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Children's (\u2264\u200917\u2009years) DXA data in NHANES (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096120) were used to generate sex\u2010 and age\u2010specific deciles of appendicular skeletal muscle mass index and fat mass index with the Lambda Mu Sigma method. Four phenotypes (high [H] or low [L], adiposity [A] and muscle mass [M]: HA\u2010HM, HA\u2010LM, LA\u2010HM, LA\u2010LM) were identified based on being above\/below the median compared to same\u2010sex and same\u2010age peers. These reference curves were applied to the QUALITY cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009630, 8\u201310\u2009years of age in 2005) to assess whether the phenotypes correctly identified cardiometabolic risk at baseline, follow\u2010up (2008\u20132010), and their longitudinal changes. Multiple linear regression models were adjusted for age, sex, and Tanner's stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the LA\u2010HM reference group, the HA\u2010HM phenotype was associated with less favourable HDL, triglycerides, and HOMA\u2010IR at baseline and first follow\u2010up, but not in their changes. The HA\u2010LM phenotype was associated with less favourable HOMA\u2010IR at baseline and first follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results suggest that phenotypes based on fat and muscle mass may have clinical utility in children and should be further investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.70051","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:56:13Z","timestamp":1756461373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Application of Children's Sex\u2010 and Age\u2010Specific Fat\u2010Mass and Muscle\u2010Mass Reference Curves From Dual\u2010Energy X\u2010Ray Absorptiometry Data for Predicting Cardiometabolic Risk"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6244-9805","authenticated-orcid":false,"given":"Stephanie Tanasia","family":"Saputra","sequence":"first","affiliation":[{"name":"Department of Mathematics and Statistics Concordia University  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5743-4876","authenticated-orcid":false,"given":"Andraea","family":"Van Hulst","sequence":"additional","affiliation":[{"name":"Ingram School of Nursing McGill University  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-2389","authenticated-orcid":false,"given":"M\u00e9lanie","family":"Henderson","sequence":"additional","affiliation":[{"name":"Centre de Recherche CHU Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al  Quebec Canada"},{"name":"Department of Pediatrics Universit\u00e9 de Montr\u00e9al  Quebec Canada"},{"name":"School of Public Health Department of Social and Preventive Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Brugiapaglia","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Concordia University  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Faustini","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Concordia University  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-7643","authenticated-orcid":false,"given":"Lisa","family":"Kakinami","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Concordia University  Quebec Canada"},{"name":"School of Health, Concordia University  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Canada PHA of \u201cTackling Obesity in Canada: Childhood Obesity and Excess Weight Rates in Canada \u201d2018 https:\/\/www.canada.ca\/en\/public\u2010health\/services\/publications\/healthy\u2010living\/obesity\u2010excess\u2010weight\u2010rates\u2010canadian\u2010children.html."},{"key":"e_1_2_12_3_1","unstructured":"National Institute of Diabetes and Digestive and Kidney Diseases \u201cOverweight & Obesity Statistics \u201d2021 https:\/\/www.niddk.nih.gov\/health\u2010information\/health\u2010statistics\/overweight\u2010obesity."},{"key":"e_1_2_12_4_1","unstructured":"\u201cObesity and Overweight \u201dhttps:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/obesity\u2010and\u2010overweight."},{"volume-title":"StatPearls","year":"2023","author":"Panuganti K. K.","key":"e_1_2_12_5_1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.583825"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(24)00316\u20104"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/52.6.953"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.078576"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.110765"},{"key":"e_1_2_12_11_1","unstructured":"NHANES \u201cNHANES Questionnaires Datasets and Related Documentation \u201daccessed February 13 2023 https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/default.aspx."},{"key":"e_1_2_12_12_1","unstructured":"NHANES \u201cNCHS Research Ethics Review Board Approval \u201d2022 https:\/\/www.cdc.gov\/nchs\/nhanes\/irba98.htm."},{"key":"e_1_2_12_13_1","unstructured":"NHANES \u201cNHANES 1999\u20102006 DXA Multiple Imputation Data Files \u201daccessed February 13 2023 https:\/\/wwwn.cdc.gov\/Nchs\/Nhanes\/Dxa\/Dxa.aspx."},{"key":"e_1_2_12_14_1","unstructured":"Centers for Disease Control and Prevention \u201cAnthropometry Procedures Manual \u201d2007 https:\/\/www.cdc.gov\/nchs\/data\/nhanes\/nhanes_07_08\/manual_an.pdf."},{"key":"e_1_2_12_15_1","unstructured":"Centers for Disease Control and Prevention \u201cNational Health and Nutrition Examination Survey: Technical Documentation for the 1999\u20102004 Dual Energy X\u2010Ray Absorptiometry (DXA) Multiple Imputation Data Files \u201daccessed February 20 2023 https:\/\/wwwn.cdc.gov\/nchs\/data\/nhanes\/dxa\/dxa_techdoc.pdf."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1537\/ase1911.99.141"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/52.2.214"},{"key":"e_1_2_12_18_1","unstructured":"WHO Mulitcentre Growth Reference Study Group \u201cWHO Child Growth Standards: Length\/Height\u2010for\u2010Age Weight\u2010for\u2010Age Weight\u2010for\u2010Length Weight\u2010for\u2010Height and Body Mass Index\u2010for\u2010Age: Methods and Development \u201d 2006."},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014468900000532"},{"key":"e_1_2_12_20_1","unstructured":"LMSchartmaker Pro\u201cHealth for all Children \u201daccessed February 13 2023 https:\/\/www.healthforallchildren.com\/shop\u2010base\/shop\/software\/lmschartmaker\u2010pro\/."},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/50.5.1231"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2000.tb06498.x"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr111"},{"volume-title":"Anthropometric Standardization Reference Manual","year":"1988","author":"Lohman T.","key":"e_1_2_12_25_1"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"e_1_2_12_28_1","unstructured":"M.Henderson \u201cThe QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) \u201dCohort https:\/\/clinicaltrials.gov 2022 https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03356262."},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0166\u20104328(01)00297\u20102"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1608942"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sctalk.2022.100074"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020215"},{"volume-title":"Fitness Measures and Health Outcomes in Youth","year":"2012","author":"Pate R.","key":"e_1_2_12_36_1"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9121935"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1861"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.274"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007\u20102329C"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.70051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T07:37:26Z","timestamp":1762414646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.70051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/ijpo.70051"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.70051","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"type":"print","value":"2047-6302"},{"type":"electronic","value":"2047-6310"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"assertion":[{"value":"2025-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70051"}}