{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:25Z","timestamp":1787014345275,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54GM104938"],"award-info":[{"award-number":["U54GM104938"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK129656"],"award-info":[{"award-number":["R01DK129656"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001298","name":"Presbyterian Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001298","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is the most common chronic liver disease in paediatric patients. Adult and murine studies have suggested a role for endotoxin from gram\u2010negative bacteria in the development of MASLD, but there is incomplete and conflicting evidence for its role in adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine if adolescents with biopsy\u2010proven MASLD have elevated endotoxin activity and whether endotoxin markers are associated with liver histological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Serum endotoxin core antibodies (EndoCab IgG), lipopolysaccharide binding protein (LBP), soluble CD14 (sCD14) and C\u2010reactive protein (CRP) were measured in adolescents with obesity and MASLD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946), and control groups without MASLD with obesity (Ob,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928) or normal weight (NW,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the NW group, both the MASLD and Ob groups had higher EndoCab IgG (56%), LBP (33%) and CRP (11\u2010fold), while sCD14 did not differ. LBP and CRP were positively correlated to trunk and total body fat (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.45 and 0.64, respectively), and to one another (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.42), all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001. None of the endotoxin markers varied between boys and girls, or with liver steatosis grade or fibrosis stage within the MASLD group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum markers of endotoxin activity and inflammation are increased in adolescents with obesity but are not further increased in patients with mild to moderate MASLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.70093","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T01:30:34Z","timestamp":1770773434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endotoxin Markers Are Elevated in Adolescents With Obesity With and Without Metabolic Dysfunction\u2010Associated Steatotic Liver Disease"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2152-0094","authenticated-orcid":false,"given":"Alison M.","family":"Boone","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Diabetes &amp; Endocrinology University of Oklahoma Health Campus  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa M.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Diabetes &amp; Endocrinology University of Oklahoma Health Campus  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan A.","family":"Bays","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Diabetes &amp; Endocrinology University of Oklahoma Health Campus  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsil","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Diabetes &amp; Endocrinology University of Oklahoma Health Campus  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Oklahoma Health Campus  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirish K.","family":"Palle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Gastroenterology, Hepatology &amp; Nutrition University of Oklahoma Health Campus  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Harold Hamm Diabetes Center, University of Oklahoma Health  Oklahoma City Oklahoma USA"},{"name":"Department of Biochemistry and Physiology University of Oklahoma Health Campus  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6704-9587","authenticated-orcid":false,"given":"Kevin R.","family":"Short","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Diabetes &amp; Endocrinology University of Oklahoma Health Campus  Oklahoma City Oklahoma USA"},{"name":"Harold Hamm Diabetes Center, University of Oklahoma Health  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/children4060048"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140908"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.02.030"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpg.0000000000001482"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pediatric16020025"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.07.034"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/ec\u201020\u20100490"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605\u2010021\u201005188\u20107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.110601.135414"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i19.2300"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.11.030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI186423"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.02.010"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12164"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181c7bdf1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/560620"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12510"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183282"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2018.7596"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70817"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.13194"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12423"},{"issue":"246","key":"e_1_2_9_24_1","first-page":"1","article-title":"2000 CDC Growth Charts for the United States: Methods and Development","volume":"11","author":"Kuczmarski R. 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