{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:44:14Z","timestamp":1790289854882,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In children, the impact of specific fat depots, particularly ectopic depots, on cardiometabolic health has been scarcely investigated. Therefore, we aimed to investigate the associations of various specific fat depots with cardiometabolic risk and insulin resistance in children with overweight\/obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred fourteen children with overweight\/obesity (54.4% girls, 10.6\u2009\u00b1\u20091.1\u2009years) were included. Fat depots including abdominal visceral (VAT), subcutaneous (ASAT), and intermuscular (IMAAT) adipose tissue, lumbar spine bone marrow, hepatic and pancreatic fat were measured using magnetic resonance imaging. Cardiometabolic risk factors (blood pressure, triglycerides, high\u2010density lipoprotein cholesterol, glucose and insulin) were assessed, and age\u2010 and sex\u2010reference based cardiometabolic risk score and insulin resistance were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In univariate analysis, VAT, ASAT, IMAAT and hepatic fat were significantly associated with cardiometabolic risk score (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.308\u20130.526,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001) and insulin resistance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.227\u20130.412,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, after adjusting for other fat variables, VAT was the only fat depot independently associated with cardiometabolic risk score (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.450,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while ASAT was the only fat depot independently associated with insulin resistance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.393,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Hepatic fat did not show an independent association with either cardiometabolic risk score or insulin resistance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2265\u20090.256).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this population, VAT and ASAT appear to be independent predictors of cardiometabolic risk and insulin resistance, respectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.70097","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:41:41Z","timestamp":1772984501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-9108","authenticated-orcid":false,"given":"Cristina","family":"Cadenas\u2010Sanchez","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Medrano","sequence":"additional","affiliation":[{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Granada Spain"},{"name":"ELIKOS Research Group, Department of Health Sciences, Institute for Sustainability &amp; Food Chain Innovation Public University of Navarra  Pamplona Spain"},{"name":"IdiSNA, Navarra Institute for Health Research  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddi","family":"Os\u00e9s","sequence":"additional","affiliation":[{"name":"ELIKOS Research Group, Department of Health Sciences, Institute for Sustainability &amp; Food Chain Innovation Public University of Navarra  Pamplona Spain"},{"name":"IdiSNA, Navarra Institute for Health Research  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Concepci\u00f3n","sequence":"additional","affiliation":[{"name":"IdiSNA, Navarra Institute for Health Research  Pamplona Spain"},{"name":"Department of Electrical, Electronic and Communications Engineering Public University of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Cabeza","sequence":"additional","affiliation":[{"name":"Department of Electrical, Electronic and Communications Engineering Public University of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Villanueva","sequence":"additional","affiliation":[{"name":"IdiSNA, Navarra Institute for Health Research  Pamplona Spain"},{"name":"Department of Electrical, Electronic and Communications Engineering Public University of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Idoate","sequence":"additional","affiliation":[{"name":"Radiology Department, Mutua Navarra, Department of Health Sciences Public University of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6897-6961","authenticated-orcid":false,"given":"Michael I.","family":"Goran","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Pediatrics Children's Hospital Los Angeles  California Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan R.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS) University of Granada  Granada Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria, ibs.Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idoia","family":"Labayen","sequence":"additional","affiliation":[{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN) Instituto de Salud Carlos III  Granada Spain"},{"name":"ELIKOS Research Group, Department of Health Sciences, Institute for Sustainability &amp; Food Chain Innovation Public University of Navarra  Pamplona Spain"},{"name":"IdiSNA, Navarra Institute for Health Research  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)02750\u20102"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883\u2010023\u201001111\u20104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(19)30084\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883\u2010022\u201000996\u2010x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092358"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010023\u201001969\u20105"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21\u20100129"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/db23\u20101005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010022\u201000784\u20102"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3142"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103205"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010021\u201000573\u20103"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000741"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010023\u201002709\u20109"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000178028"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db23\u20100450"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.207"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20100351\/\u2010\/DC1"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2015.09.017"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047\u20106310.2012.00064.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047\u20106310.2014.00217.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.43864"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad429"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.10.003"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00645.2007"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6522.746"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpo.12653"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i15.4688"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000771"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.675355"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20135"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20101378"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.12.007"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.267"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010024\u201002127\u20101"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab541"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102019\u2010001126"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31018"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20674"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13311"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318244a685"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem\u20102018\u20100315"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13090724"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae547"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007\u20102089"}],"container-title":["Pediatric Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.70097","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijpo.70097","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijpo.70097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:02:55Z","timestamp":1774418575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijpo.70097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/ijpo.70097"],"URL":"https:\/\/doi.org\/10.1111\/ijpo.70097","archive":["Portico"],"relation":{},"ISSN":["2047-6302","2047-6310"],"issn-type":[{"value":"2047-6302","type":"print"},{"value":"2047-6310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70097"}}