{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T09:04:41Z","timestamp":1779786281141,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5R01DK120598"],"award-info":[{"award-number":["5R01DK120598"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antihypertensive class medications are prescribed long\u2010term for adolescents, including for conditions other than hypertension. Evidence on weight effects is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the weight effects of commonly prescribed antihypertensive class medications among adolescents, regardless of clinical indication for use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study was conducted using electronic health record (EHR) data from a multi\u2010site US research network. The study cohort included adolescents aged 13.0\u201319.5\u2009years with \u2265\u20091 antihypertensive class medication order during 2010\u20132019. Weight and height documented in the EHR were used to calculate BMI z\u2010scores. Inverse probability weighting with marginal structural models was used to account for selection factors and covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 23\u2009853 adolescents were prescribed an antihypertensive class medication, including clonidine (prescribed to\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097491), guanfacine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096411), lisinopril (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093584), propranolol (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093015), spironolactone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091926), and atenolol (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091426). At baseline, 13% had a hypertension diagnosis. At 12\u2009months after medication initiation, the estimated population\u2010level BMI z\u2010score was significantly increased for propranolol (BMI z\u2010score 0.19 [95% CI 0.09, 0.29]) and significantly decreased for lisinopril (\u22120.06 [95% CI \u22120.10, \u22120.01]); clonidine, guanfacine, spironolactone, and atenolol were not associated with a significant change in BMI z\u2010score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most antihypertensive class medications were not associated with statistically significant weight gain when prescribed to adolescents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.70114","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:36:16Z","timestamp":1779352576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Common Antihypertensive Class Medications on\n                    <scp>BMI<\/scp>\n                    z\u2010Score in Adolescents"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1309-4096","authenticated-orcid":false,"given":"Matthew F.","family":"Daley","sequence":"first","affiliation":[{"name":"Institute for Health Research, Kaiser Permanente Colorado  Aurora Colorado USA"},{"name":"Department of Pediatrics University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-920X","authenticated-orcid":false,"given":"Sheryl L.","family":"Rifas\u2010Shiman","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-6932","authenticated-orcid":false,"given":"Jessica G.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-5931","authenticated-orcid":false,"given":"Joshua","family":"Petimar","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4879-2193","authenticated-orcid":false,"given":"Carly","family":"Prentice","sequence":"additional","affiliation":[{"name":"Faith Family Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-0662","authenticated-orcid":false,"given":"L. Charles","family":"Bailey","sequence":"additional","affiliation":[{"name":"Applied Clinical Research Center, Department of Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-610X","authenticated-orcid":false,"given":"David M.","family":"Janicke","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology College of Public Health and Health Professions, University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9706-6860","authenticated-orcid":false,"given":"William J.","family":"Heerman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-9064","authenticated-orcid":false,"given":"Jason P.","family":"Block","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts 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