{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:42:50Z","timestamp":1790289770741,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011852","name":"Paracelsus Medizinische Privatuniversit\u00e4t","doi-asserted-by":"publisher","award":["2023\u2010IiF\u2010Schaffler\u2010Schaden"],"award-info":[{"award-number":["2023\u2010IiF\u2010Schaffler\u2010Schaden"]}],"id":[{"id":"10.13039\/501100011852","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Polygenic risk scores (PRS) stratify obesity risk in population cohorts, but their value within specialised paediatric obesity clinics\u2014where genetic liability may already be saturated\u2014remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed 246 European adolescents with overweight and obesity (mean\u2009\u00b1\u2009SD age 13.3\u2009\u00b1\u20092.2\u2009years; 51% female; BMI 31.6\u2009\u00b1\u20094.1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) attending a tertiary clinic in Salzburg, Austria. BMI\u2010PRS based on people with European ancestry (PGS000027) and two cardiometabolic PRS (Homeostasis Model Assessment of Insulin Resistance [HOMA\u2010IR], type 2 diabetes [T2D]) were computed from Axiom\u2010array genotypes. Distributions were compared with a population\u2010based adult cohort from the same region (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092044). Associations with BMI, insulin resistance (HOMA\u2010IR \u2265\u20092.5), alanine aminotransferase (ALT) and oral\u2010glucose\u2010tolerance parameters were examined by linear and logistic regression adjusted for age and sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The adolescent cohort showed a right\u2010shifted BMI\u2010PRS distribution; the lowest quintile exceeded the adult mean (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Within the clinic sample, BMI\u2010PRS neither correlated with BMI (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.11; 95% CI \u22120.23 to 0.02) nor predicted other parameters investigated. PRS for HOMA\u2010IR and T2D showed similarly null associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a genetically enriched clinical cohort, polygenic scores lose discriminatory power, delineating their optimal use for population screening rather than intra\u2010clinic risk stratification. These data underscore the strong hereditary architecture of paediatric obesity and support context\u2010specific application of precision\u2010medicine tools.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.70132","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:55:17Z","timestamp":1782960917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Body Mass Index Polygenic Risk Score (\n                    <scp>BMI<\/scp>\n                    \u2010\n                    <scp>PRS<\/scp>\n                    ) in a Paediatric Population With Obesity"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5112-9347","authenticated-orcid":false,"given":"Julian","family":"Gomahr","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Hospital Salzburg, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Lauth","sequence":"additional","affiliation":[{"name":"Team Biostatistics and Big Medical Data, IDA Lab Salzburg PMU Salzburg  Salzburg Austria"},{"name":"Research Programme Biomedical Data Science, PMU Salzburg  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"S\u00fc\u00dfenbacher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Salzburg, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Bergauer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Salzburg, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Forer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital 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Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"M\u00f6rwald","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Salzburg, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Langthaler","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University Hospital Salzburg, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Iglseder","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Christian\u2010Doppler\u2010Klinik Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Paulweber","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University Hospital Salzburg, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Flamm","sequence":"additional","affiliation":[{"name":"Institute of General Practice, Family\u2010 and Preventive Medicine, Paracelsus Medical University  Salzburg Austria"},{"name":"Center for Public Health and Healthcare Research, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Aigner","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine University Hospital Salzburg, Paracelsus Medical University  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocritical Care, and Neurorehabilitation Christian Doppler University Hospital, Paracelsus Medical University and Centre for Cognitive Neuroscience, 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