{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:18:28Z","timestamp":1787872708544,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005415","name":"H\u00e1sk\u00f3li \u00cdslands","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005415","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Real\u2010world evidence of subsidised semaglutide in children with obesity is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe clinical outcomes (%IOTF30 change) in a nationwide cohort of Icelandic children prescribed subsidised semaglutide, describing outcomes across treatment settings and examining treatment response in children with and without neurodevelopmental disorders (ND).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, population\u2010based cohort study using longitudinal anthropometric measurements, March 20, 2021\u2013June 6, 2025. Children aged \u2265\u200912 with grade 2 obesity were eligible for subsidised semaglutide under a universal reimbursement policy. Main outcomes were changes in %IOTF30 (BMI expressed as a percentage of the age\u2010 and sex\u2010specific IOTF obesity threshold), modelled using piecewise linear mixed\u2010effects regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 113 participants (44% female; mean [SD] age 15.2 [2.0] years), pre\u2010treatment %IOTF30 rose at 0.29 percentage points (pp)\/month (95% CI, 0.26, 0.33). Semaglutide was associated with trajectory reversal at \u22120.86\u2009pp\/month (95% CI, \u22121.06 to \u22120.66); estimated reductions were 5.17 (95% CI, 3.98, 6.36) and 10.33 (95% CI, 7.96, 12.71) pp at six and 12\u2009months. On\u2010treatment slopes were numerically similar across settings but not interpretable as evidence of equivalent response. ND\u2010status did not significantly modify treatment response among 56 Pediatric Obesity Center participants (interaction\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.83; underpowered). Overall, 63% achieved %IOTF30 reductions exceeding 10\u2009pp.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide was associated with reversal of a longstanding upward weight trajectory in children with obesity. ND\u2010status did not significantly modify treatment response; analysis was underpowered. Universal subsidisation policy enabled high treatment persistence and may inform reimbursement policy in other countries, though generalisability to settings without universal coverage remains uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijpo.70139","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:00:19Z","timestamp":1785751219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Use of Subsidised Semaglutide in Icelandic Children With Obesity: A Nationwide Retrospective Cohort Study"],"prefix":"10.1111","volume":"21","author":[{"given":"Sigrun","family":"Thorsteinsdottir","sequence":"first","affiliation":[{"name":"Faculty of Health Promotion, Sport and Leisure Studies University of Iceland  Reykjav\u00edk Iceland"},{"name":"The Pediatric Obesity Center, Children's Hospital, The National University Hospital of Iceland  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berglind","family":"Jonsdottir","sequence":"additional","affiliation":[{"name":"The Pediatric Obesity Center, Children's Hospital, The National University Hospital of Iceland  Reykjav\u00edk Iceland"},{"name":"Faculty of Medicine University of Iceland  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna S.","family":"Olafsdottir","sequence":"additional","affiliation":[{"name":"Faculty of Health Promotion, Sport and Leisure Studies University of Iceland  Reykjav\u00edk Iceland"},{"name":"The Pediatric Obesity Center, Children's Hospital, The National University Hospital of Iceland  Reykjav\u00edk Iceland"},{"name":"Department of Food Studies Nutrition and Dietetics, Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena B.","family":"Arnarsdottir","sequence":"additional","affiliation":[{"name":"The Pediatric Obesity Center, Children's Hospital, The National University Hospital of Iceland  Reykjav\u00edk Iceland"},{"name":"Faculty of Medicine University of Iceland  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Hallgrimsdottir","sequence":"additional","affiliation":[{"name":"The Pediatric Obesity Center, Children's Hospital, The National University Hospital of Iceland  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berglind","family":"Brynj\u00f3lfsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"The Pediatric Obesity Center, Children's Hospital, The National University Hospital of Iceland  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tryggvi","family":"Helgason","sequence":"additional","affiliation":[{"name":"The Pediatric Obesity Center, Children's Hospital, The National University Hospital of Iceland  Reykjav\u00edk Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)02750\u20102"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.36660\/ijcs.20240146"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci14010070"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9121866"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/children11020205"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2024.5552"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922815615825"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010020\u20101498\u2010z"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010024\u201004835\u20107"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21693"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941406412448527"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rasd.2019.04.002"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010016\u20102963\u20106"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/chi.2022.0230"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000552403"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1438786"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1332598"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/aut.2020.0080"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022\u2010060640"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S419245"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000001379"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208601"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024\u2010068119"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102023\u2010326687"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0314787"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010082446"},{"key":"e_1_2_12_28_1","unstructured":"\u201cIcelandic 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