{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:18:43Z","timestamp":1787872723145,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD104028"],"award-info":[{"award-number":["R21HD104028"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002014"],"award-info":[{"award-number":["UL1TR002014"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Formula feeding and having a mother with overweight are associated with overweight during infancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We sought to pilot test calibrated formula feeding guidance using age and weight specific intake recommendations to improve weight outcomes amongst at\u2010risk infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Exclusively formula fed newborns with birthweight\u2009\u2265\u200950th percentile delivered to mothers with pre\u2010pregnancy body mass index (BMI)\u2009\u2265\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      were randomised to intervention and usual care groups. At monthly visits from 1 to 5\u2009months, mothers of intervention group infants with weight\u2010for\u2010length (WFL)\u2009\u2265\u200975th percentile were advised to give 10% less daily formula than required based upon sex, age and weight. The primary outcome was conditional weight gain (CWG) between birth and 6\u2009months. Secondary outcomes included WFL\n                      <jats:italic>z<\/jats:italic>\n                      \u2010score and overweight (WFL\u2009\u2265\u200995th percentile) at 6\u2009months, as well as growth trajectory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty infants were enrolled; 36 mothers (66.7%) had pre\u2010pregnancy BMI\u2009\u2265\u200930. Seventeen (28.3%) withdrew before 6\u2009months. At each assessment, a minority had WFL\u2009\u2265\u200975th percentile required to receive calibrated formula guidance. There were no group differences in CWG (intervention mean 0.27, 95% CI \u22120.20 to 0.75 vs. control mean \u22120.12, 95% CI \u22120.62 to 0.37;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.25) or for secondary outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Calibrated infant formula recommendations were not associated with growth outcomes.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      Clinicaltrials.gov identifier: NCT05104073 (registered October 11, 2021)\n                    <\/jats:p>\n                  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