{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:18:25Z","timestamp":1787872705725,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["200310013"],"award-info":[{"award-number":["200310013"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Obesity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background\/Objectives<\/jats:title>\n Umbilical cord leptin is increased in infants of women with obesity. We tested the hypothesis that a high cord leptin\u2010to\u2010fat mass ratio might be associated with adverse outcomes at birth and in early childhood.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A secondary analysis of vitamin\n \n D A<\/jats:styled-content>\n <\/jats:italic>\n nd\n \n L<\/jats:styled-content>\n <\/jats:italic>\n ifestyle\n \n I<\/jats:styled-content>\n <\/jats:italic>\n ntervention for gestational diabetes mellitus prevention (DALI) trial was conducted. Cord leptin\u2010to\u2010fat mass ratios were classified into top (TT), middle, and low (LT) tertiles overall and within sexes. Relationship with neonatal outcomes and offspring BMI\n z<\/jats:italic>\n \u2010scores were compared between TT and LT groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 323 infants (maternal pre\u2010pregnancy BMI 33.7\u2009\u00b1\u20094.2\u2009kg\/m\n \n 2<\/jats:styled-content>\n <\/jats:sup>\n , 52% male) female (vs. male) offspring had higher cord leptin, fat mass percentage, and leptin\u2010to\u2010fat mass ratio (median (IQR): 21.4 (13.4, 30.99) vs. 15.5 (8.3, 25.9),\n p<\/jats:italic>\n \u2009<\u20090.001). Compared to the LT group, infants in the TT group (58% females) had higher cord leptin but similar fat mass percentage. Among males (but not in females), the C\u2010peptide\u2010to\u2010glucose ratio was elevated in the TT group (vs. LT) (0.2 (0.1\u20130.2) vs. 0.1(0.02\u20130.2),\n p<\/jats:italic>\n \u2009<\u20090.001), while birthweight (3.5\u2009\u00b1\u20090.5 vs. 3.7\u2009\u00b1\u20090.4\u2009kg,\n p<\/jats:italic>\n \u2009=\u20090.045), fat mass percentage (11.1\u2009\u00b1\u20093.9 vs. 13.0\u2009\u00b1\u20093.6,\n p<\/jats:italic>\n \u2009=\u20090.008), and BMI\n z<\/jats:italic>\n \u2010scores (at age 1 only) were lower (median (IQR): \u22120.15 (\u22120.67, 0.98) vs. 1.35 (\u22120.06, 1.67),\n p<\/jats:italic>\n \u2009=\u20090.03).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Relative cord hyperleptinaemia was associated with reduced offspring BMI among males.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijpo.70144","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T03:47:20Z","timestamp":1787370440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Relative Cord Hyperleptinemia and Offspring Outcomes in Pregnant Women With Overweight or Obesity"],"prefix":"10.1111","volume":"21","author":[{"given":"Jincy","family":"Immanuel","sequence":"first","affiliation":[{"name":"School of Medicine Western Sydney University Sydney Australia"},{"name":"College of Nursing Texas Woman's University Denton Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3165-3156","authenticated-orcid":false,"given":"Stephy","family":"Chirayath","sequence":"additional","affiliation":[{"name":"College of Nursing Texas Woman's University Denton Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Harreiter","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Division of Endocrinology, Gender Medicine Unit Medical University of Vienna Vienna Austria"},{"name":"Department of Medicine and Palliative Care Landesklinikum Scheibbs Scheibbs Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-3230","authenticated-orcid":false,"given":"Gernot","family":"Desoye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medizinische Universitaet Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5055-6814","authenticated-orcid":false,"given":"Rosa","family":"Corcoy","sequence":"additional","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Institut de Recerca de L'hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"CIBER Bioengineering, Biomaterials and Nanotechnology Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Adelantado","sequence":"additional","affiliation":[{"name":"REALIFE Research Group, Department of Development and Regeneration KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Devlieger","sequence":"additional","affiliation":[{"name":"REALIFE Research Group, Department of Development and Regeneration KU Leuven Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9207-7704","authenticated-orcid":false,"given":"Annunziata","family":"Lapolla","sequence":"additional","affiliation":[{"name":"Universita Degli Studi di Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3011-0521","authenticated-orcid":false,"given":"Maria G.","family":"Dalfra","sequence":"additional","affiliation":[{"name":"Universita Degli Studi di Padova Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bertolotto","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero\u2013Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wender\u2013Ozegowska","sequence":"additional","affiliation":[{"name":"Department of Reproduction Poznan University of Medical Sciences Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Zawiejska","sequence":"additional","affiliation":[{"name":"Department of Reproduction Poznan University of Medical Sciences Poznan 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M.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Odense Odense University Hospital Odense Denmark"},{"name":"Department of Gynecology and Obstetrics Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research, Faculty of Health Science University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Lotte T.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research, Faculty of Health Science University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette H.","family":"Tanvig","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Odense University Hospital Odense Denmark"},{"name":"Department of Clinical Research, Faculty of Health Science University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-5678","authenticated-orcid":false,"given":"David J.","family":"Hill","sequence":"additional","affiliation":[{"name":"Lawson Research Institute London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith G. M.","family":"Jelsma","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Vrije Universiteit Amsterdam, Department of Public and Occupational Health, Amsterdam Public Health Research Institute Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-4105","authenticated-orcid":false,"given":"Alexandra","family":"Kautzky\u2013Willer","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Division of Endocrinology, Gender Medicine Unit Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Galjaard","sequence":"additional","affiliation":[{"name":"REALIFE Research Group, Department of Development and Regeneration KU Leuven Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology University Hospitals Leuven Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Snoek","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Vrije Universiteit Amsterdam, Department of Medical Psychology Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille N. 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