{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:08:40Z","timestamp":1769105320110,"version":"3.49.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T00:00:00Z","timestamp":1377475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diagnosing paroxysmal atrial fibrillation in patients with stroke can be difficult. We aimed to determine if N-terminal pro-brain natriuretic peptide can help identify paroxysmal atrial fibrillation in cryptogenic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Among 264 ischemic stroke patients, serum levels of N-terminal pro-brain natriuretic peptide were measured within 72 h of stroke onset. In cryptogenic stroke patients, 24-h Holter monitoring was used to look for paroxysmal atrial fibrillation within the first week and also three-and six-months after admission. First, patients with a defined etiology were used to construct a receiver operating characteristic curve for the diagnosis of atrial fibrillation. From this curve, the sensitivity and specificity of preestablished cutoff points for the diagnosis of atrial fibrillation were calculated. A logistic regression was performed to assess the independent relationship of the logarithm of N-terminal pro-brain natriuretic peptide levels with atrial fibrillation. The cutoff points were then evaluated in patients with cryptogenic stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred eighty-four patients had a specific stroke etiology. Fifty-five patients had atrial fibrillation. Using multivariate analysis, the logarithm of N-terminal pro-brain natriuretic peptide levels was independently associated with atrial fibrillation. The area under the receiver operating characteristic curve of N-terminal pro-brain natriuretic peptide for the diagnosis of atrial fibrillation was 0\u00b791 (95% confidence interval 0\u00b787\u20130\u00b795). The cutoff point of 265\u00b75 pg\/ml had a sensitivity of 100% and specificity of 70\u00b75% for the diagnosis of atrial fibrillation. The cutoff point of 912 pg\/ml had a sensitivity of 81\u00b78% and a specificity of 87\u00b75%. Eighty patients had a cryptogenic stroke. In 17, paroxysmal atrial fibrillation was found during follow-up. In these patients, the area under the curve for the diagnosis of paroxysmal atrial fibrillation was 0\u00b783. The cutoff point of 265\u00b75 had a sensitivity of 88\u00b72% and a specificity of 61\u00b79%. The cutoff point of 912 pg\/ml had a sensitivity of 47\u00b71% and a specificity of 88\u00b79%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>N-terminal pro-brain natriuretic peptide has good accuracy in predicting the presence of paroxysmal atrial fibrillation in patients with cryptogenic stroke and can help to identify these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijs.12126","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T02:17:43Z","timestamp":1377569863000},"page":"419-425","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["<i>N<\/i>-Terminal Pro-Brain Natriuretic Peptide Shows Diagnostic Accuracy for Detecting Atrial Fibrillation in Cryptogenic Stroke Patients"],"prefix":"10.1177","volume":"9","author":[{"given":"Ana Catarina","family":"Fonseca","sequence":"first","affiliation":[{"name":"Department of Neurosciences 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Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis R.","family":"Caplan","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Neurosciences (Neurology), Hospital de Santa Maria, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,8,26]]},"reference":[{"key":"bibr1-ijs.12126","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000166053.83476.4a"},{"key":"bibr2-ijs.12126","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03376-3"},{"key":"bibr3-ijs.12126","doi-asserted-by":"crossref","first-page":"e257","DOI":"10.1161\/circ.114.4.257","volume":"114","author":"Morais 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