{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:14:56Z","timestamp":1759482896343,"version":"3.38.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Background Chlamydia pneumoniae<\/jats:title><jats:p> infection and the risk of cerebral infarction have been previously studied in several publications; however, conflicting results have been reported. This meta-analysis assessed whether C. pneumoniae infection was associated with risk of cerebral infarction. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Systematic computerized searches of the PubMed and Web of Knowledge were performed. Adjusted odds ratio and 95% confidence interval from original studies were extracted for combined meta-analysis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Twenty-three studies with 2924 cerebral infarction patients and 4692 control patients were included in the meta-analysis. When the positive C. pneumoniae infection was defined by microimmunofluorescence-detected immunoglobulin A, the pooled odds ratio between two groups was 2\u00b704 (95% confidence interval 1\u00b742\u20132\u00b79). In the most frequently used immunoglobulin A \u2a7e1:16 sub-group, the pooled odds ratio was 2\u00b707 (95% confidence interval 1\u00b731\u20133\u00b726). When the infection was defined by enzyme-linked immunosorbent assay-detected immunoglobulin A, the pooled odds ratio was 2\u00b789 (95% confidence interval 1\u00b723\u20136\u00b781). When the infection was defined by microimmunofluorescence-detected immunoglobulin G, the pooled odds ratio was 1\u00b746 (95% confidence interval 1\u00b718\u20131\u00b781). In the most frequently used immunoglobulin G \u2a7e1:32 sub-group, the pooled odds ratio was 1\u00b743 (95% confidence interval 1\u00b706\u20131\u00b792). When the infection was defined by enzyme-linked immunosorbent assay-detected immunoglobulin G, the pooled odds ratio was 1\u00b754 (95% confidence interval 0\u00b786\u20132\u00b774). No significant publication bias was found. Sensitivity analyses showed the results were robust. Conclusion ( 1 ) This meta-analysis indicated that C. pneumoniae infection was significantly associated with an increased risk of cerebral infarction. ( 2 ) Compared with anti- C. pneumoniae immunoglobulin G, anti- C. pneumoniae immunoglobulin A seemed more effective for predicting the risk of cerebral infarction. ( 3 ) No evidence existed that anti- C. pneumoniae-immunoglobulin G detected by enzyme-linked immunosorbent assay could predict the risk of cerebral infarction. <\/jats:p><\/jats:sec>","DOI":"10.1111\/ijs.12248","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T01:54:22Z","timestamp":1394070862000},"page":"356-364","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Chlamydia Pneumoniae<\/i> Infection and Cerebral Infarction Risk: A Meta-Analysis"],"prefix":"10.1177","volume":"9","author":[{"given":"Xing","family":"Su","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Nantong University, Nantong, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,3,5]]},"reference":[{"key":"bibr1-ijs.12248","unstructured":"who.int. 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