{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:48:27Z","timestamp":1783579707783,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T00:00:00Z","timestamp":1401148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"US National Institute of Health-National Institute of Neurological Disorders and Stroke (NIH-NINDS)","award":["U01NS038529"],"award-info":[{"award-number":["U01NS038529"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Neuroimaging manifestations of small vessel disease are heterogeneous, and correlation with patient features has not been adequately characterized. <\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p> Our goal was to correlate magnetic resonance imaging findings with clinical features in a large multiethnic cohort with recent lacunar stroke. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Patient characteristics were correlated with neuroimaging results in the Secondary Prevention of Small Subcortical Stroke study participants. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Among 3005 patients, mean age was 63 years; 62% were men; and 51%, 30%, and 16% were non-Hispanic White, Hispanic, and Black, respectively. Recent lacunar infarcts were distributed between the subcortical hemisphere (31%), thalamus (26%), brainstem\/cerebellum (26%), and basal ganglia\/internal capsule (16%). Multiple lacunar infarcts (i.e., acute and remote) were present in 40% and associated with increased age (OR 1\u00b73 per 20 years, 95% CI 1\u00b71, 1\u00b75), male gender (OR 1\u00b75, CI 1\u00b73, 1\u00b77), hypertension (OR 1\u00b75, CI 1\u00b72, 1\u00b78), increased systolic blood pressure (OR 1\u00b72 per 20 mmHg, CI 1\u00b71, 1\u00b73), and prior stroke (OR 3\u00b78, CI 2\u00b79, 5\u00b70). Moderate-severe white matter hyperintensities were present in 50% and associated with increased age (OR 4\u00b73 per 20 years, CI 3\u00b74, 5\u00b74), hypertension (OR 1\u00b78, CI 1\u00b74, 2\u00b73), increased systolic blood pressure (OR 1\u00b73 per 20mmHg, CI 1\u00b71, 1\u00b75), increased diastolic blood pressure (OR 1\u00b72 per 10 mm, CI 1\u00b70,1\u00b73), and prior stroke (OR 3\u00b73, CI 2\u00b73, 4\u00b75). Infarct location varied significantly by race-ethnicity ( P &lt; 0\u00b7001), with Blacks and Hispanics having more infarcts in the brainstem\/cerebellum than non-Hispanic Whites, and by gender with women more often having thalamic lacunes than men ( P \u2264 0\u00b7001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> In patients with recent lacunar stroke, infarct location and number have distinctie associations with gender, vascular risk factors, and race-ethnicity, demonstrating the complex pathogenesis of lacunar stroke and cerebral small artery disease. <\/jats:p><\/jats:sec>","DOI":"10.1111\/ijs.12282","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T09:57:02Z","timestamp":1401184622000},"page":"1057-1064","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical\u2013MRI Correlations in a Multiethnic Cohort with Recent Lacunar Stroke: The SPS3 Trial"],"prefix":"10.1177","volume":"9","author":[{"given":"Oscar R.","family":"Benavente","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Neurology, Brain Research Center, University of British Columbia, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesly A.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Biostatistics Consultant, Minot, ND, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Bazan","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Roldan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Catanese","sequence":"additional","affiliation":[{"name":"Department of Neurology, Boston University Medical Center (BUMC). Boston, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viveca M. Bhat","family":"Livezey","sequence":"additional","affiliation":[{"name":"South Puget Sound Neurology, Tacoma, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Vidal-Pergola","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"McClure","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology), McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the SPS3 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