{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:46Z","timestamp":1787014366952,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T00:00:00Z","timestamp":1440547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Disconnected Mind"},{"DOI":"10.13039\/501100000360","name":"Scottish Funding Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000360","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council (BBSRC)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council (EPSRC)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000269","name":"Economic and Social Research Council (ESRC)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MRC"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim and\/or hypothesis<\/jats:title>\n                    <jats:p>To test for independent associations between two Alzheimer's disease-susceptibility gene loci \u2013 APOE \u03b5 and the TOMM40 \u2018523\u2019 poly-T repeat \u2013 and white matter hyperintensities\/cerebral microbleed burden in community-dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants in the Lothian Birth Cohort 1936 underwent genotyping for APOE \u03b5 and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72\u00b770 years (standard deviation = 0\u00b77; range = 71\u201374).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant effects of APOE \u03b5 or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijs.12615","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T22:48:09Z","timestamp":1440629289000},"page":"1297-1300","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["<i>APOE\/TOMM40<\/i>\n                    Genetic Loci, White Matter Hyperintensities, and Cerebral Microbleeds"],"prefix":"10.1177","volume":"10","author":[{"given":"Donald M.","family":"Lyall","sequence":"first","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK"},{"name":"Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK"},{"name":"Department of Psychology, University of Edinburgh, Edinburgh, UK"},{"name":"Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Mu\u00f1oz Maniega","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK"},{"name":"Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK"},{"name":"Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Harris","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK"},{"name":"Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Bastin","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK"},{"name":"Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK"},{"name":"Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Murray","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK"},{"name":"Department of Psychology, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Lutz","sequence":"additional","affiliation":[{"name":"Joseph & Kathleen Bryan Alzheimer's Disease Research Center, Department of Neurology, Duke University Medical Center, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Joseph & Kathleen Bryan Alzheimer's Disease Research Center, Department of Neurology, Duke University Medical Center, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen D.","family":"Roses","sequence":"additional","affiliation":[{"name":"Joseph & Kathleen Bryan Alzheimer's Disease Research Center, Department of Neurology, Duke University Medical Center, Durham, NC, USA"},{"name":"Zinfandel Pharmaceuticals, Inc., Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"del C. Vald\u00e9s Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK"},{"name":"Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK"},{"name":"Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Royle","sequence":"additional","affiliation":[{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK"},{"name":"Brain Research Imaging Centre, Division of Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK"},{"name":"Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences, The University of Edinburgh, Edinburgh, 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