{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:04:45Z","timestamp":1760346285911},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T00:00:00Z","timestamp":1353283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Objectives<\/jats:title>To clarify the prevalence of lower urinary tract symptoms and overactive bladder in patients with chronic methyl mercury poisoning.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 151 patients (61 men and 90 women; mean age 72.1 years) with N<\/jats:styled-content>iigata M<\/jats:styled-content>inamata disease were enrolled. An age\u2010 and sex\u2010matched group of 150 participants was used as control. Patients reported their International Prostate Symptom Score and overactive bladder symptom score.<\/jats:p><\/jats:sec>Results<\/jats:title>In men, the total, storage and voiding International Prostate Symptom Score scores were higher in the N<\/jats:styled-content>iigata M<\/jats:styled-content>inamata disease group than in the control group (10.6\u2009\u00b1\u20097.8 vs<\/jats:italic> 5.0\u2009\u00b1\u20095.0, 4.5\u2009\u00b1\u20093.3 vs<\/jats:italic> 2.4\u2009\u00b1\u20092.4 and 6.1\u2009\u00b1\u20095.1 vs<\/jats:italic> 2.7\u2009\u00b1\u20093.1, respectively, P<\/jats:italic>\u2009<\u20090.001 in all). In women, these scores were also higher in the N<\/jats:styled-content>iigata M<\/jats:styled-content>inamata disease group than in the control group (8.9\u2009\u00b1\u20097.3 vs<\/jats:italic> 4.0\u2009\u00b1\u20094.0, 4.4\u2009\u00b1\u20093.2 vs<\/jats:italic> 2.8\u2009\u00b1\u20092.4 and 4.5\u2009\u00b1\u20095.0 vs<\/jats:italic> 1.3\u2009\u00b1\u20092.0, respectively, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001 in all). The prevalence of overactive bladder was more frequent in the N<\/jats:styled-content>iigata M<\/jats:styled-content>inamata disease group compared with that in the control group (51.7% vs<\/jats:italic> 26.7%, P<\/jats:italic>\u2009<\u20090.001). In both men and women, the overactive bladder symptom score was higher in the N<\/jats:styled-content>iigata M<\/jats:styled-content>inamata disease group than in the control group (4.1\u2009\u00b1\u20093.0 vs<\/jats:italic> 2.4\u2009\u00b1\u20092.9, P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.002 and 4.6\u2009\u00b1\u20093.6 vs<\/jats:italic> 2.7\u2009\u00b1\u20092.9, P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001, respectively). The International Prostate Symptom Score and overactive bladder symptom score in the N<\/jats:styled-content>iigata M<\/jats:styled-content>inamata disease group were highest in patients aged 60\u201369 years (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.001 in both), whereas these increased in an age\u2010dependent manner in the control group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Lower urinary tract symptoms and overactive bladder are severe and highly prevalent conditions among patients with methyl mercury poisoning. The higher prevalence of lower urinary tract symptoms among patients aged 60\u201369 years might be related to the fact that they were exposed to methyl mercury during their childhood\/development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12001","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T01:02:23Z","timestamp":1353373343000},"page":"610-615","source":"Crossref","is-referenced-by-count":7,"title":["Lower urinary tract symptoms in patients with N<\/scp>iigata M<\/scp>inamata disease: A case\u2013control study 50 years after methyl mercury pollution"],"prefix":"10.1111","volume":"20","author":[{"given":"Noboru","family":"Hara","sequence":"first","affiliation":[{"name":"Division of Urology Department of Regenerative and Transplant Medicine Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kido Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Urology Department of Regenerative and Transplant Medicine Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Urology Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.06.036"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2000.00295.x"},{"key":"e_1_2_8_4_1","first-page":"166","volume-title":"Minamata Disease Methylmercury Poisoning in Minamata and Niigata, Japan","author":"Iwata K","year":"1977"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/14.4.582"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.147"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20792"},{"key":"e_1_2_8_8_1","first-page":"147","volume-title":"Minamata Disease","author":"Tsubaki T","year":"1977"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001920050010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.09.019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0045(19980201)34:2<121::AID-PROS6>3.0.CO;2-N"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.03.035"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00587-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2009.10.017"},{"key":"e_1_2_8_15_1","first-page":"635075","article-title":"MethylMercury Exposure at Niigata, Japan: results of neurological examinations of 103 adults","author":"Maruyama K","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2009.11.020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/10590500903310120"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.12001","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.12001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T03:41:11Z","timestamp":1697341271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.12001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,19]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/iju.12001"],"URL":"https:\/\/doi.org\/10.1111\/iju.12001","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,19]]}}}