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Men with high\u2010risk or locally\u2010advanced prostate cancer require treatment to the primary cancer or risk dying prematurely from their disease. Increasingly, combined androgen deprivation therapy\u2009+\u2009radiation treatment is seen as the standard treatment as a result of prospective studies in this space, and the perceived increased morbidity of radical prostatectomy in the setting of a \u201clow\u201d cure rate as monotherapy. In the absence of a well\u2010conducted randomized trial, there is no definite evidence that one treatment is superior to the other. The advantages of radical prostatectomy are that it provides excellent local control of the primary tumor without an increase in morbidity, accurately stages the disease to guide further therapy, and removes benign sources of prostate\u2010specific antigen so that failures can be promptly identified and subsequent treatment can be initiated in a timely manner. Although several guidelines recommend radiation treatment over radical prostatectomy as first\u2010line treatment, there is no evidence that surgery is inferior and radical prostatectomy should remain part of any informed discussion regarding treatment options for men with high\u2010risk prostate cancer.<\/jats:p>","DOI":"10.1111\/iju.12069","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T20:56:55Z","timestamp":1357851415000},"page":"290-300","source":"Crossref","is-referenced-by-count":18,"title":["Radical prostatectomy in high\u2010risk prostate cancer"],"prefix":"10.1111","volume":"20","author":[{"given":"Joseph","family":"Ischia","sequence":"first","affiliation":[{"name":"Vancouver Prostate Centre Vancouver General Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gleave","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre Vancouver General Hospital  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06260.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61095-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61815-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-008-0250-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.09.016"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.11.969"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.6004\/jnccn.2007.0056","article-title":"Updating the prostate cancer guidelines","volume":"5","author":"Mohler JL","year":"2007","journal-title":"J. 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