{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:16Z","timestamp":1787014396980,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,3,24]],"date-time":"2013-03-24T00:00:00Z","timestamp":1364083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify predictive factors of bladder recurrence after radical nephroureterectomy and to evaluate the impact of this event on oncological outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We carried out a retrospective analysis of 237 patients treated with radical nephroureterectomy for urothelial carcinoma of the upper tract at our institution from 1998 to 2011. Univariable and multivariable models evaluated the prognostic factors of bladder recurrence, and its impact on recurrence\u2010free survival and cancer\u2010specific survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age was 69.3 years (interquartile range 60\u201376). With a median follow up of 44 months (interquartile range 24\u201379), bladder recurrence occurred in 85 patients (35.9%). A previous history of bladder cancer (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) and the presence of concomitant carcinoma\n                      <jats:italic>in\u2009situ<\/jats:italic>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005) remained independent predictors of bladder recurrence. The presence of bladder recurrence was not correlated with worse oncological outcomes in terms of disease recurrence (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.075) and cancer\u2010specific mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.06). However, the patients who experienced muscle\u2010invasive bladder cancer recurrence had worse outcomes in terms of cancer\u2010specific mortality (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). Standard pathological features of aggressiveness, such as higher tumor stage (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05), higher grade (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) and carcinoma\n                      <jats:italic>in\u2009situ<\/jats:italic>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03), were independent predictors of muscle\u2010invasive bladder cancer recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Previous history of bladder cancer, tumor location and concomitant carcinoma\n                      <jats:italic>in\u2009situ<\/jats:italic>\n                      are independent predictors of bladder recurrence in patients undergoing radical nephroureterectomy. Bladder recurrence overall does not impact the oncological outcomes, but a muscle\u2010invasive bladder recurrence is associated with a worse cancer\u2010specific mortality. Standard pathological features of urothelial carcinoma of the upper tract aggressiveness (\n                      <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>\n                      \u2010stage, grade) are independent predictors of muscle\u2010invasive bladder cancer recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iju.12121","type":"journal-article","created":{"date-parts":[[2013,3,24]],"date-time":"2013-03-24T20:46:41Z","timestamp":1364158001000},"page":"1078-1083","source":"Crossref","is-referenced-by-count":29,"title":["Bladder recurrence after radical nephroureterectomy: Predictors and impact on oncological outcomes"],"prefix":"10.1111","volume":"20","author":[{"given":"Vincent","family":"Elalouf","sequence":"first","affiliation":[{"name":"Department of Urology and Pathology Cochin Hospital APHP Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evanguelos","family":"Xylinas","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology Cochin Hospital APHP Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Klap","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology Cochin Hospital APHP Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Pignot","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology Cochin Hospital APHP Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas Barry","family":"Delongchamps","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology Cochin Hospital APHP Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djilali","family":"Saighi","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology Cochin Hospital APHP Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Peyromaure","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology Cochin Hospital APHP Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Flam","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology Cochin Hospital APHP Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Zerbib","sequence":"additional","affiliation":[{"name":"Department of Urology and Pathology Cochin Hospital APHP Paris Descartes University  Paris 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