{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:16:36Z","timestamp":1791090996993,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cold stress as a result of whole\u2010body cooling at low environmental temperatures exacerbates lower urinary tract symptoms, such as urinary urgency, nocturia and residual urine. We established a model system using healthy conscious rats to explore the mechanisms of cold stress\u2010induced detrusor overactivity. In this review, we summarize the basic findings shown by this model. Rats that were quickly transferred from room temperature (27\u2009\u00b1\u20092\u00b0C) to low temperature (4\u2009\u00b1\u20092\u00b0C) showed detrusor overactivity including increased basal pressure and decreased voiding interval, micturition volume, and bladder capacity. The cold stress\u2010induced detrusor overactivity is mediated through a resiniferatoxin\u2010sensitve <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010fiber sensory nerve pathway involving \u03b11\u2010adrenergic receptors. Transient receptor potential melastatin\u20098 channels, which are sensitive to thermal changes below 25\u201328\u00b0C, also play an important role in mediating the cold stress responses. Additionally, the sympathetic nervous system is associated with transient hypertension and decreases of skin surface temperature that are closely correlated with the detrusor overactivity. With this cold stress model, we showed that \u03b11\u2010adrenergic receptor antagonists have the potential to treat cold stress\u2010exacerbated lower urinary tract symptoms. In addition, we showed that traditional <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese herbal mixtures composed of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>achimijiogan act, in part, by increasing skin temperature and reducing the number of cold sensitive transient receptor potential melastatin channels in the skin. The effects of herbal mixtures have the potential to treat and\/or prevent the exacerbation of lower urinary tract symptoms by providing resistance to the cold stress responses. Our model provides new opportunities for utilizing animal disease models with altered lower urinary tract functions to explore the effects of novel therapeutic drugs.<\/jats:p>","DOI":"10.1111\/iju.12129","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T03:55:16Z","timestamp":1361937316000},"page":"661-669","source":"Crossref","is-referenced-by-count":24,"title":["Cold stress induces lower urinary tract symptoms"],"prefix":"10.1111","volume":"20","author":[{"given":"Tetsuya","family":"Imamura","sequence":"first","affiliation":[{"name":"Department of Lower Urinary Tract Medicine Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ishizuka","sequence":"additional","affiliation":[{"name":"Department of Lower Urinary Tract Medicine Shinshu University School of Medicine  Matsumoto Nagano Japan"},{"name":"Department of Urology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Lower Urinary Tract Medicine Shinshu University School of Medicine  Matsumoto Nagano Japan"},{"name":"Department of Urology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20497"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1580\/PR30-04.1"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2005.01372.x"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198502000-00010"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20305"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000170235.22776.1a"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590701485921"},{"key":"e_1_2_14_9_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1757-5672.2012.00151.x","article-title":"Relationship between toe temperature and lower urinary tract symptoms","volume":"4","author":"Inoue H","year":"2012","journal-title":"LUTS"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20630"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20774"},{"key":"e_1_2_14_12_1","article-title":"Functional roles of transient receptor potential melastatin 8 (TRPM8) channels in the cold stress\u2010induced detrusor overactivity pathways in conscious rats","author":"Lei Z","year":"2012","journal-title":"Neurourol. Urodyn."},{"key":"e_1_2_14_13_1","article-title":"The relationship between Alpha1\u2010Adrenergic receptors and TRPM8 channels in detrusor overactivity induced by cold stress in ovariectomized rats","author":"Noguchi W","year":"2012","journal-title":"J. Urol."},{"key":"e_1_2_14_14_1","article-title":"Galenical produced from Ba\u2010Wei\u2010Die\u2010Huang\u2010Wan (THC\u2010002) provides resistance to the cold stress\u2010induced detrusor overactivity in conscious rats","author":"Imamura T","year":"2012","journal-title":"Neurourol. Urodyn."},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.12.100"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.12.031"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00588-0"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-6-31"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.05.021"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2005.06.028"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0205-105"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2008.07.063"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350120"},{"key":"e_1_2_14_24_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrn3173","article-title":"Sensory transduction: how TRPs discriminate between different stimuli","volume":"13","author":"Lewis S","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-002-1059-8"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature719"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00652-9"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/35097164"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.10.023"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2005.01.013"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.01.074"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-47"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.04.017"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.02.024"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283424c9c"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.179"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808487106"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.05.047"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705652"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.012146"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0836"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052324"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000167087.81927.a6"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599.2010.515611"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20984"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00553.2009"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20559"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20702"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.129.957"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X06003837"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21179"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2005-2901(09)60018-2"},{"key":"e_1_2_14_53_1","first-page":"1","article-title":"Thermographic evaluation of the efficacy of Kampo medicines","volume":"55","author":"Inokawa M","year":"2006","journal-title":"Hiroshima J. Med. Sci."},{"issue":"2","key":"e_1_2_14_54_1","article-title":"Chinese herbal medicines for hyperthyroidism","author":"Zen XX","year":"2007","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.12129","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.12129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:53:19Z","timestamp":1696297999000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.12129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,26]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/iju.12129"],"URL":"https:\/\/doi.org\/10.1111\/iju.12129","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,26]]}}}