{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:20:23Z","timestamp":1775082023719,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To report discontinuation rates, inter\u2010injection interval and complication rates after repeated intravesical botulinum toxin type\u2009<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> for the treatment of detrusor overactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with urodyamically proven detrusor overactivity who had two or more botulinum toxin type\u2009<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> injections in the period 2004\u20132011 at Freeman Hospital, Newcastle Upon Tyne, UK, were considered for the present study. Discontinuation rates, complication rates and interval between botulinum toxin type\u2009<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> treatments were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 125 patients (median age 53 years, range 19\u201383 years) were included in the analysis. The female\u2010to\u2010male ratio was 2.4:1 and median follow up was 38 months. A total of 96 patients had idiopathic detrusor overactivity, whereas 29 had neurogenic detrusor overactivity. A total of 667 injections were carried out, with 125 patients receiving two injections, 60 receiving three injections, 28 receiving four injections, 14 receiving five injections, three receiving six injections, three receiving seven injections and two receiving eight injections. The mean interval (\u00b1standard deviation) between the first and second injection (<jats:italic>n<\/jats:italic>\u2009=\u2009125) was 17.6\u2009months (\u00b110.4), between the second and third (<jats:italic>n<\/jats:italic>\u2009=\u200960) was 15.7\u2009\u00b1\u20097.4\u2009months, between the third and fourth (<jats:italic>n<\/jats:italic>\u2009=\u200928) was 15.4\u2009\u00b1\u20098.6 months, and between the fourth and subsequent injections (<jats:italic>n<\/jats:italic>\u2009=\u200922) was 11.6\u2009\u00b1\u20094.5 months. A total of 26% required intermittent catheterization, and 18% developed recurrent urinary tract infections. There was a discontinuation rate of 25% at 60 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repeated botulinum toxin type <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> injections represent a safe and effective method for managing patients with idiopathic detrusor overactivity and neurogenic detrusor overactivity. We have shown that the inter\u2010injection interval remains unchanged up to five injections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12205","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:08:45Z","timestamp":1372810125000},"page":"175-178","source":"Crossref","is-referenced-by-count":29,"title":["Discontinuation rates and inter\u2010injection interval for repeated intravesical botulinum toxin type\u2009<scp>A<\/scp> injections for detrusor overactivity"],"prefix":"10.1111","volume":"21","author":[{"given":"Rajan","family":"Veeratterapillay","sequence":"first","affiliation":[{"name":"Department of Urology Freeman Hospital  Newcastle Upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Harding","sequence":"additional","affiliation":[{"name":"Department of Urology Freeman Hospital  Newcastle Upon Tyne 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