{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:31:38Z","timestamp":1765827098120},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between body mass index and oncological outcomes in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients who had undergone radical nephroureterectomy for upper urinary tract urothelial carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 1998 and <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ctober 2009, 236 consecutive <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients underwent radical nephroureterectomy for upper urinary tract urothelial carcinoma at Sun Yat\u2010sen University Cancer Center (Guangzhou, China). Body mass index data were available for 230 (97.5%) of these patients. All 230 patients were classified into three groups according to the body mass index criteria for <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sians, issued by the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sia <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ohort <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>onsortium: underweight, body mass index &lt;18.5\u2009kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>n<\/jats:italic>\u2009=\u200921, 9.1%); normal weight, body mass index \u226518.5 and &lt;25\u2009kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>n<\/jats:italic>\u2009=\u2009151, 65.7%); and obesity, body mass index \u226525\u2009kg\/m<jats:sup>2<\/jats:sup>, (<jats:italic>n<\/jats:italic>\u2009=\u200958, 25.2%). Spearman's rank correlation, <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier plots and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox proportional hazards regression model were used to analyze the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Being underweight was significantly associated with lymph node metastasis (<jats:italic>P<\/jats:italic>\u2009=\u20090.017) and Eastern Cooperative Oncology Group performance status (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). Univariate analysis showed recurrence\u2010free survival and cancer\u2010specific survival were significantly worse in underweight patients than in patients with normal weight or obese patients. After adjustments for other clinicopathological variables, multivariate analysis confirmed that recurrence\u2010free survival and cancer\u2010specific survival were significantly worse in underweight patients than in patients with normal weight or obese patients (recurrence\u2010free survival <jats:italic>P<\/jats:italic>\u2009=\u20090.014, cancer\u2010specific survival <jats:italic>P<\/jats:italic>\u2009=\u20090.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative underweight is an independent predictor of unfavorable recurrence\u2010free survival and cancer\u2010specific survival in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients with upper urinary tract urothelial carcinoma treated by radical nephroureterectomy, whereas obesity is associated with superior recurrence\u2010free survival and cancer\u2010specific survival. Further studies, including a multi\u2010institutional, prospective, <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian cohort study, are required to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12208","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T10:22:43Z","timestamp":1376302963000},"page":"136-142","source":"Crossref","is-referenced-by-count":16,"title":["Influence of body mass index on oncological outcomes in patients with upper urinary tract urothelial carcinoma treated with radical nephroureterectomy"],"prefix":"10.1111","volume":"21","author":[{"given":"Jian\u2010Ye","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Sun Yat\u2010sen University Cancer Center  Guangzhou Guangdong China"},{"name":"Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou Guangdong 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