{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:13:53Z","timestamp":1791346433760,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,4]],"date-time":"2013-08-04T00:00:00Z","timestamp":1375574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the pathological relationship between metabolic syndrome and peri\u2010urethral fibrosis status secondary to chronic prostate inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peri\u2010urethral prostate tissue from 80 consecutive patients who underwent retropubic radical prostatectomy for prostate cancer was analyzed. Patients were divided in two groups according to whether or not they had a diagnosis of metabolic syndrome. A 16\u2010peri\u2010urethral core bench biopsy was carried out on each radical prostatectomy specimen to evaluate the extent of peri\u2010urethral inflammatory infiltrate, and collagen and elastin amount. Spearman's correlation analysis was used to test the association between variables. Furthermore, the data were used to define a bivariate logistic regression model in which the presence (&gt;50% collagen amount for each patients) or absence (\u226450% collagen amount) of fibrosis was analyzed after adjusting for clinical and pathological variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant difference was found between the two groups in terms of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rostatic <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptoms <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>core (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and urodynamics findings (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Patients with metabolic syndrome showed a more extended inflammatory infiltrate and higher peri\u2010urethral collagen amount, along with a lower peri\u2010urethral elastin amount (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). A positive correlation was observed between inflammation, <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rostatic <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptoms <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>core, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ladder <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>utlet <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>bstruction <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex and collagen amount, whereas inflammation was inversely correlated with elastin amount. On multivariate logistic regression analysis, prostate inflammation and metabolic syndrome were the only independent predictors of peri\u2010urethral fibrosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.73, 1.52, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present findings suggest that metabolic syndrome might represent an independent risk factor for prostate inflammation and fibrotic changes secondary to inflammation within the peri\u2010urethral prostatic tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12233","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:25:56Z","timestamp":1375662356000},"page":"264-269","source":"Crossref","is-referenced-by-count":21,"title":["Metabolic syndrome correlates with peri\u2010urethral fibrosis secondary to chronic prostate inflammation: Evidence of a link in a cohort of patients undergoing radical prostatectomy"],"prefix":"10.1111","volume":"21","author":[{"given":"Francesco","family":"Cantiello","sequence":"first","affiliation":[{"name":"Urology Unit Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"},{"name":"Doctorate Research Program Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cicione","sequence":"additional","affiliation":[{"name":"Urology Unit Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"},{"name":"Doctorate Research Program Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Salonia","sequence":"additional","affiliation":[{"name":"Doctorate Research Program Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"},{"name":"Urological Research Institute University Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Autorino","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ucciero","sequence":"additional","affiliation":[{"name":"Urology Unit Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"},{"name":"Doctorate Research Program Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tucci","sequence":"additional","affiliation":[{"name":"Department of Pathology Pugliese\u2010Ciaccio Hospital  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Doctorate Research Program Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"},{"name":"Urological Research Institute University Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Damiano","sequence":"additional","affiliation":[{"name":"Urology Unit Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"},{"name":"Doctorate Research Program Magna Gr\u00e6cia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.06.038"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.00972.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eursup.2009.11.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.055"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.12.011"},{"issue":"4","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0022-5347(18)35422-3","article-title":"The impact of acute or chronic inflammation in baseline biopsy on the risk of clinical progression of BPH: results from the MTOPS study","volume":"173","author":"Roehrborn CG","year":"2005","journal-title":"J. Urol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.06.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.11.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2012.44"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0b013e3283336f3f"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.3.356"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-48"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0094-0143(21)00968-X","article-title":"Principles and clinical application of advanced urodynamic analysis of voiding function","volume":"17","author":"Schafer W","year":"1990","journal-title":"Urol. Clin. North Am."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00121.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-007-0146-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64957-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2011.112"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20110"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32814db856"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.147835"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.07.016"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22662"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500221"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.05.040"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.04.025"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.10.027"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.09.034"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.12.024"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10298"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.12233","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.12233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:28:58Z","timestamp":1696228138000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.12233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,4]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/iju.12233"],"URL":"https:\/\/doi.org\/10.1111\/iju.12233","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,4]]}}}