{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:54:30Z","timestamp":1791644070232,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J of Urology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 on male sexual behavior in a rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sexual behavior was examined after an acute oral administration of 10, 30 or 100\u2009mg\/kg of <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 in copulation studies with female rats. Pharmacokinetic parameters were calculated after oral administration of <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 at a dose level of 30\u2009mg\/kg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 treatment produced a dose\u2010dependent increase in ejaculation latency time and showed statistical significance at 30 and 100\u2009mg\/kg dosage levels compared with the vehicle (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In addition, <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 treatment reduced the mean number of ejaculations in a dose\u2010dependent manner. No changes in post\u2010ejaculatory interval, numbers of mounts, intromissions or ejaculations were observed at any dose. In pharmacokinetic study, the blood concentration of <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 peaked at 0.38\u2009\u00b1\u20090.14\u2009h after oral administration, and then rapidly declined with a half\u2010life of 1.79\u2009\u00b1\u20090.32\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 delays the ejaculation latency time without affecting the initiation of mounting behavior or post\u2010ejaculatory interval in rats. Furthermore, <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 is rapidly absorbed and eliminated after oral administration in rats. These preclinical findings provide a clue for the clinical testing of <jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>\u20108031 as an \u201con\u2010demand\u201d agent for premature ejaculation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iju.12256","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T00:32:42Z","timestamp":1377217962000},"page":"325-329","source":"Crossref","is-referenced-by-count":12,"title":["Effect of <scp>DA<\/scp>\u20108031, a novel oral compound for premature ejaculation, on male rat sexual behavior"],"prefix":"10.1111","volume":"21","author":[{"given":"Kyung Koo","family":"Kang","sequence":"first","affiliation":[{"name":"Research Institute of Dong\u2010A Pharmaceutical Company  Yong\u2010in Kyoung\u2010gi South Korea"},{"name":"College of Pharmacy Ajou University  Yeongtong Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Sung","sequence":"additional","affiliation":[{"name":"Research Institute of Dong\u2010A Pharmaceutical Company  Yong\u2010in Kyoung\u2010gi South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Hoe","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute of Dong\u2010A Pharmaceutical Company  Yong\u2010in Kyoung\u2010gi South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhyang","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy Ajou University  Yeongtong Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.6.537"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901250"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.00163.x"},{"key":"e_1_2_8_5_1","first-page":"743","article-title":"Utility of selective serotonin reuptake inhibitors in premature ejaculation","volume":"5","author":"Waldinger MD","year":"2004","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.20112.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287212453866"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64146-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767040-00005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000132159.61156.ea"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(99)00048-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005284850"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009359183"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.01.025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CE.S13841"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/11587660-000000000-00000"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01509.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.09.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.11.046"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.12.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(98)00051-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(96)00036-0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161205774913363"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-004-0493-x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(98)00015-7"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00437.x"},{"issue":"3","key":"e_1_2_8_27_1","first-page":"200","article-title":"Actions of dapoxetine on ejaculation and sexual behavior in rats","volume":"3","author":"Gengo P","year":"2006","journal-title":"J. Sex. Med."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-2186-6"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-001-0980-3"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01173.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04252.x"}],"container-title":["International Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiju.12256","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iju.12256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:29:07Z","timestamp":1696228147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iju.12256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,22]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/iju.12256"],"URL":"https:\/\/doi.org\/10.1111\/iju.12256","archive":["Portico"],"relation":{},"ISSN":["0919-8172","1442-2042"],"issn-type":[{"value":"0919-8172","type":"print"},{"value":"1442-2042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,22]]}}}